1PPF: Human leukocyte elastase

X-ray crystal structure of the complex of human leukocyte elastase (pmn elastase) and the third domain of the turkey ovomucoid inhibitor. Determined by X-ray diffraction at 1.8 Å resolution. Released 31 Jan 1994.

Method: X-ray diffraction
Resolution: 1.8 Å
Organisms: Homo sapiens, Meleagris gallopavo
Chains: 2
Atoms: 2,518
Mol. weight: 32.19 kDa
Released: 31 Jan 1994

Explore 1PPF in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1PPF contains 10 α-helices and 26 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain E: 9 helices, 22 β-strands

Element	Residues	Length	Sheet
β-strand	17	1	1
β-strand	20-21	2	2
α-helix	22-23	2
β-strand	30-35	6	3
β-strand	39-48	10	3
β-strand	51-54	4	3
α-helix	56-58	3
α-helix	63A-63C	3
β-strand	65-68	4	3
β-strand	72	1	4
β-strand	81-83	3	3
β-strand	85-90	6	3
β-strand	95	1	5
β-strand	100	1	5
β-strand	104-108	5	3
α-helix	112-114	3
α-helix	120-122	3
α-helix	124-125	2
α-helix	128-130	3
β-strand	135-140	6	2
β-strand	143	1	6
β-strand	151	1	6
β-strand	154	1	4
β-strand	156-162	7	2
β-strand	181-184	4	2
β-strand	189	1	1
β-strand	198-201	4	2
β-strand	208-217	10	2
β-strand	226-230	5	2
α-helix	231-234	4
α-helix	235-242	8

Chain I: 1 helix, 4 β-strands

Element	Residues	Length	Sheet
β-strand	15-17	3	2
β-strand	23-25	3	7
β-strand	30-31	2	7
α-helix	34-43	10
β-strand	50-53	4	7

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Human leukocyte elastase	E	protein	218	Homo sapiens	P08246 (AlphaFold model)
Turkey ovomucoid inhibitor (OMTKY3)	I	protein	56	Meleagris gallopavo	P68390 (AlphaFold model)

Sequence of entity 1 (E), FASTA

>1PPF_1 HUMAN LEUKOCYTE ELASTASE (chains E)
IVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNL
SRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGV
QCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCN
GLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQ

Sequence of entity 2 (I), FASTA

>1PPF_2 TURKEY OVOMUCOID INHIBITOR (OMTKY3) (chains I)
LAAVSVDCSEYPKPACTLEYRPLCGSDNKTYGNKCNFCNAVVESNGTLTLSHFGKC

Primary citation

X-ray crystal structure of the complex of human leukocyte elastase (PMN elastase) and the third domain of the turkey ovomucoid inhibitor. Bode, W., Wei, A.Z., Huber, R. et al. EMBO J (1986) 5:2453-2458. PubMed

Other PDB entries of the same protein (UniProt P08246 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9SI4 1.14 Å, Structure of human neutrophil elastase in complex with a…
8VK5 1.56 Å, Human Sputum Leucocyte Elastase (uncomplexed)
5ABW 1.6 Å, Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases
4WVP 1.63 Å, Crystal structure of an activity-based probe HNE complex
2Z7F 1.7 Å, Crystal structure of the complex of human neutrophil elastase with 1/2SLPI
9ASS 1.75 Å, Crystal Structure of Neutrophil Elastase Inhibited by Eap4 from S. aureus
5A0A 1.78 Å, Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone…
2RG3 1.8 Å, Covalent complex structure of elastase
8G25 1.8 Å, Crystal Structure of Cathepsin-G and Neutrophil Elastase Inhibited by S. aureus EapH2 at…
5A09 1.81 Å, Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone…
8G24 1.82 Å, Crystal Structure of Cathepsin-G and Neutrophil Elastase Inhibited by S. aureus EapH2 at…
1HNE 1.84 Å, Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone…

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