1QSG: Enoyl reductase inhibition by triclosan

Crystal structure of enoyl reductase inhibition by triclosan. Determined by X-ray diffraction at 1.75 Å resolution. Released 21 Jul 1999.

Method

X-ray diffraction

Resolution

1.75 Å

Organism

Escherichia coli

Chains

8

Atoms

17,287

Mol. weight

234.47 kDa

Ligands

TCL, NAD, GLC

Released

21 Jul 1999

Explore 1QSG in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1QSG contains 145 α-helices and 72 β-strands across 8 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 17 helices, 9 β-strands

Molecules and chains

>1QSG_1 ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE (chains A, B, C, D, E, F, G, H)
GSHMGFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGS
DIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAH
DISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAM
GPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLS
AGISGEVVHVDGGFSIAAMNELELK

Ligands and cofactors

Primary citation

Structural basis and mechanism of enoyl reductase inhibition by triclosan. Stewart, M.J., Parikh, S., Xiao, G. et al. J Mol Biol (1999) 290:859-865. DOI 10.1006/jmbi.1999.2907 · PubMed

Related structures

Other PDB entries of the same protein (UniProt P0AEK4 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 7UMW 1.54 Å, Crystal structure of E. Coli FabI in complex with NAD and Fabimycin…
• 7UM8 1.7 Å, Crystal structure of E. Coli FabI in complex with NAD and…
• 4CV2 1.8 Å, Crystal structure of E. coli FabI in complex with NADH and CG400549
• 1QG6 1.9 Å, Crystal structure of E. Coli enoyl acyl carrier protein reductase in complex with NAD…
• 3PJF 1.9 Å, Structure of ENR G93V mutant-NAD+-triclosan complex
• 4CV3 1.95 Å, Crystal structure of E. coli FabI in complex with NADH and PT166
• 5CFZ 1.97 Å, Crystal structure of E. coli FabI in apo form
• 1C14 2.0 Å, Crystal structure of E coli enoyl reductase-NAD+-triclosan complex
• 4D46 2.0 Å, Crystal structure of E. coli FabI in complex with NAD and…
• 5CG1 2.07 Å, Crystal structure of E. coli FabI bound to the carbamoylated benzodiazaborine inhibitor…
• 1DFI 2.09 Å, X-ray structure of escherichia coli enoyl reductase with bound NAD
• 5CG2 2.11 Å, Crystal structure of E. coli FabI bound to the thiocarbamoylated benzodiazaborine…

Browse structure collections

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