1TP3: PDZ3 domain of PSD-95 protein

PDZ3 domain of PSD-95 protein complexed with KKETPV peptide ligand. Determined by X-ray diffraction at 1.99 Å resolution. Released 20 Sept 2005.

Method: X-ray diffraction
Resolution: 1.99 Å
Organisms: Rattus norvegicus, synthetic
Chains: 2
Atoms: 974
Mol. weight: 13.44 kDa
Released: 20 Sept 2005

Explore 1TP3 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1TP3 contains 6 α-helices and 9 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 6 helices, 8 β-strands

Element	Residues	Length	Sheet
α-helix	302-304	3
α-helix	306-308	3
β-strand	312-317	6	1
β-strand	325-329	5	1
α-helix	331-333	3
β-strand	336-341	6	1
α-helix	346-349	4
β-strand	357-362	6	1
β-strand	365-366	2	1
α-helix	372-380	9
β-strand	385-392	8	1
α-helix	394-398	5
β-strand	404-406	3	2
β-strand	412-414	3	2

Chain B: 0 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	422-424	3	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Presynaptic density protein 95	A	protein	119	Rattus norvegicus	P31016 (AlphaFold model)
KKETPV peptide ligand	B	protein	6	synthetic

Sequence of entity 1 (A), FASTA

>1TP3_1 Presynaptic density protein 95 (chains A)
GSPEFLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKG
DQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEANSRVDSSGRIVTD

Sequence of entity 2 (B), FASTA

>1TP3_2 KKETPV peptide ligand (chains B)
KKETPV

Primary citation

Structure of the third PDZ domain of PSD-95 protein complexed with KKETPV peptide ligand. Saro, D., Martin, P., Vickrey, J.F. et al. To be published.

Other PDB entries of the same protein (UniProt P31016 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5HEY 1.5 Å, The third PDZ domain from the synaptic protein PSD-95 (G330T mutant) in complex with a…
5MZ7 1.53 Å, Crystal Structure of the third PDZ domain from the synaptic protein PSD-95 with…
1TP5 1.54 Å, Crystal structure of PDZ3 domain of PSD-95 protein complexed with a peptide ligand KKETWV
5HFD 1.6 Å, The third PDZ domain from the synaptic protein PSD-95 (G330T, H372A double mutant)
5HFB 1.62 Å, The third PDZ domain from the synaptic protein PSD-95 (H372A mutant) in complex with a…
5HEB 1.65 Å, The third PDZ domain from the synaptic protein PSD-95 in complex with a C-terminal…
5HED 1.7 Å, The third PDZ domain from the synaptic protein PSD-95 in complex with a mutant…
5HF1 1.75 Å, The third PDZ domain from the synaptic protein PSD-95 (G330T mutant) in complex with a…
5HFF 1.75 Å, The third PDZ domain from the synaptic protein PSD-95 (G330T, H372A double mutant) in…
5HF4 1.75 Å, The third PDZ domain from the synaptic protein PSD-95 (H372A mutant)
1KJW 1.8 Å, SH3-Guanylate Kinase Module from PSD-95
5HFE 1.8 Å, The third PDZ domain from the synaptic protein PSD-95 (G330T, H372A double mutant) in…

Browse structure collections

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