1UMO: Cytoglobin

The crystal structure of cytoglobin: the fourth globin type discovered in man. Determined by X-ray diffraction at 2.59 Å resolution. Released 2 Sept 2004.

Method: X-ray diffraction
Resolution: 2.59 Å
Organism: HOMO SAPIENS
Chains: 2
Atoms: 2,713
Mol. weight: 44.04 kDa
Ligands: HEM
Released: 2 Sept 2004

Explore 1UMO in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1UMO contains 16 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 0 β-strands

Element	Residues	Length
α-helix	21-36	16
α-helix	38-52	15
α-helix	54-59	6
α-helix	69-94	26
α-helix	99-115	17
α-helix	122-138	17
α-helix	140-142	3
α-helix	145-167	23

Chain B: 8 helices, 0 β-strands

Element	Residues	Length
α-helix	21-35	15
α-helix	38-52	15
α-helix	54-59	6
α-helix	69-72	4
α-helix	76-94	19
α-helix	99-115	17
α-helix	122-138	17
α-helix	145-168	24

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Cytoglobin	A, B	protein	190	HOMO SAPIENS	Q8WWM9 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>1UMO_1 CYTOGLOBIN (chains A, B)
MEKVPGEMEIERRERSEELSEAERKAVQAMWARLYANSEDVGVAILVRFFVNFPSAKQYF
SQFKHMEDPLEMERSPQLRKHASRVMGALNTVVENLHDPDKVSSVLALVGKAHALKHKVE
PVYFKILSGVILEVVAEEFASDFPPETQRAWAKLRGLIYSHVTAAYKEVGWVQQVPNATT
PPATLPSSGP

Ligands and cofactors

ID	Name	Formula	Copies
HEM	Protoporphyrin IX containing FE	C34 H32 Fe N4 O4	2

Primary citation

Crystal structure of cytoglobin: the fourth globin type discovered in man displays heme hexa-coordination. de Sanctis, D., Dewilde, S., Pesce, A. et al. J Mol Biol (2004) 336:917-927. DOI 10.1016/j.jmb.2003.12.063 · PubMed

Other PDB entries of the same protein (UniProt Q8WWM9 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2DC3 1.68 Å, Crystal structure of human cytoglobin at 1.68 angstroms resolution
1URV 2.0 Å, Crystal structure of cytoglobin: the fourth globin type discovered in man displays heme…
1UT0 2.1 Å, Crystal structure of cytoglobin: the fourth globin type discovered in man displays heme…
1URY 2.4 Å, cytoglobin cavities
1UX9 2.4 Å, Mapping protein matrix cavities in human cytoglobin through Xe atom binding: a…
1V5H 2.4 Å, Crystal Structure of Human Cytoglobin (Ferric Form)
3AG0 2.6 Å, Crystal structure of carbonmonoxy human cytoglobin
4B3W 2.8 Å, Crystal structure of human cytoglobin H(E7)Q mutant

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