1W0U: HTRF2 DNA-binding domain

hTRF2 DNA-binding domain in complex with telomeric DNA. Determined by X-ray diffraction at 1.8 Å resolution. Released 22 Dec 2004.

Method: X-ray diffraction
Resolution: 1.8 Å
Organism: HOMO SAPIENS
Chains: 4
Atoms: 1,723
Mol. weight: 23.53 kDa
Released: 22 Dec 2004

Explore 1W0U in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1W0U contains 8 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and B: 4 helices, 0 β-strands

Element	Residues	Length
α-helix	449-451	3
α-helix	452-465	14
α-helix	470-476	7
α-helix	484-496	13

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Telomeric repeat binding factor 2	A, B	protein	55	HOMO SAPIENS	Q15554 (AlphaFold model)
5'-d(tpcptpapgpgpgptptpap gpgpgptptpap*g)-3'	C	DNA	17
5'-d(cptpapapcpcpcptpapap cpcpcptpapgp*a)-3'	D	DNA	17

Sequence of entity 1 (A, B), FASTA

>1W0U_1 TELOMERIC REPEAT BINDING FACTOR 2 (chains A, B)
KKQKWTVEESEWVKAGVQKYGEGNWAAISKNYPFVNRTAVMIKDRWRTMKRLGMN

Sequence of entity 2 (C), FASTA

>1W0U_2 5'-D(*TP*CP*TP*AP*GP*GP*GP*TP*TP*AP *GP*GP*GP*TP*TP*AP*G)-3' (chains C)
TCTAGGGTTAGGGTTAG

Sequence of entity 3 (D), FASTA

>1W0U_3 5'-D(*CP*TP*AP*AP*CP*CP*CP*TP*AP*AP *CP*CP*CP*TP*AP*GP*A)-3' (chains D)
CTAACCCTAACCCTAGA

Primary citation

How the Human Telomeric Proteins Trf1 and Trf2 Recognize Telomeric DNA: A View from High-Resolution Crystal Structures. Court, R.I., Chapman, L.M., Fairall, L. et al. EMBO Rep (2005) 6:39. DOI 10.1038/SJ.EMBOR.7400314 · PubMed

Other PDB entries of the same protein (UniProt Q15554 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3SJM 1.35 Å, Crystal Structure Analysis of TRF2-Dbd-DNA complex
3K6G 1.95 Å, Crystal structure of Rap1 and TRF2 complex
4M7C 2.05 Å, Crystal structure of the TRF2-binding motif of SLX4 in complex with the TRFH domain of…
6J67 2.05 Å, Crystal structure of the compound 34 in a complex with TRF2
3BU8 2.15 Å, Crystal Structure of TRF2 TRFH domain and TIN2 peptide complex
7C5D 2.15 Å, Crystal structure of TRF2 TRFH domain in complex with a MCPH1 peptide
1H6P 2.2 Å, Dimeristion domain from human TRF2
5XYF 2.2 Å, Crystal structure of the human TIN2-TPP1-TRF2 telomeric complex
4RQI 2.44 Å, Structure of TRF2/RAP1 secondary interaction binding site
3BUA 2.5 Å, Crystal Structure of TRF2 TRFH domain and APOLLO peptide complex
9Q9K 2.59 Å, Cryo-EM structure of human Mre11-Rad50 (MR) complex bound to DNA and telomeric factor…
9Q9J 2.71 Å, Cryo-EM structure of human Mre11-Rad50-Nbs1 (MRN) complex bound to DNA and telomeric…

Browse structure collections

About this viewer

MolViewer shows 1W0U directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.