1ZFP: Growth factor receptor binding protein

Growth factor receptor binding protein SH2 domain complexed with a phosphotyrosyl pentapeptide. Determined by X-ray diffraction at 1.8 Å resolution. Released 30 Mar 1999.

Method: X-ray diffraction
Resolution: 1.8 Å
Organism: Homo sapiens
Chains: 2
Atoms: 969
Mol. weight: 12.37 kDa
Ligands: ZN
Released: 30 Mar 1999

Explore 1ZFP in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1ZFP contains 2 α-helices and 8 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain E: 2 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	61	1	1
α-helix	67-75	9
β-strand	82-87	6	1
β-strand	95-101	7	1
β-strand	104-110	7	1
β-strand	111-112	2	2
β-strand	118-119	2	2
β-strand	124-125	2	2
α-helix	128-137	10
β-strand	149-150	2	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Growth factor receptor binding protein	E	protein	98	Homo sapiens	P62993 (AlphaFold model)
Epidermal growth factor receptor-derived peptide	I	protein	7

Sequence of entity 1 (E), FASTA

>1ZFP_1 GROWTH FACTOR RECEPTOR BINDING PROTEIN (chains E)
KPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGA
GKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQ

Sequence of entity 2 (I), FASTA

>1ZFP_2 EPIDERMAL GROWTH FACTOR RECEPTOR-DERIVED PEPTIDE (chains I)
XEYINQX

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	1

Primary citation

Structural basis for the high affinity of amino-aromatic SH2 phosphopeptide ligands. Rahuel, J., Garcia-Echeverria, C., Furet, P. et al. J Mol Biol (1998) 279:1013-1022. DOI 10.1006/jmbi.1998.1790 · PubMed

Other PDB entries of the same protein (UniProt P62993 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6ICG 1.15 Å, Grb2 SH2 domain in phosphopeptide free form
3WA4 1.35 Å, Grb2 SH2 domain/CD28-derived peptide complex
1JYR 1.55 Å, Xray Structure of Grb2 SH2 Domain Complexed with a Phosphorylated Peptide
2VWF 1.58 Å, Grb2 SH3C (2)
2VVK 1.6 Å, Grb2 SH3C (1)
3OV1 1.6 Å, Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide
4P9V 1.64 Å, Grb2 SH2 complexed with a pTyr-Ac6cN-Asn tripeptide
1GCQ 1.68 Å, Crystal structure of vav and GRB2 SH3 domains
2W0Z 1.7 Å, Grb2 SH3C (3)
3C7I 1.7 Å, X-RAY crystal structure of the complex between the grb2-sh2 domain and a flexible…
3IN8 1.7 Å, Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pTyr-Ile-Asn-NH2…
3S8L 1.71 Å, Protein-Ligand Interactions: Thermodynamic Effects Associated with Increasing…

Browse structure collections

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