28JS: Human holo-TFIIH-XPC complex
Cryo-EM structure of the human holo-TFIIH-XPC complex bound to bulky lesion-mimic DNA (composite map). Determined by electron microscopy at 3.32 Å resolution. Released 6 May 2026.
- Method
- Electron microscopy
- Resolution
- 3.32 Å
- Organisms
- Homo sapiens, synthetic construct
- Chains
- 13
- Atoms
- 30,828
- Mol. weight
- 641.64 kDa
- Ligands
- CA, ZN, SF4
- Released
- 6 May 2026
Explore 28JS in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
28JS contains 189 α-helices and 144 β-strands across 11 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 35 helices, 34 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 52-53 | 2 | 1 |
| β-strand | 59-60 | 2 | 1 |
| α-helix | 66 | 1 | |
| β-strand | 67 | 1 | 2 |
| α-helix | 68 | 1 | |
| β-strand | 76 | 1 | 3 |
| β-strand | 83-87 | 5 | 3 |
| α-helix | 94-103 | 10 | |
| β-strand | 105-108 | 4 | 3 |
| β-strand | 113-117 | 5 | 3 |
| α-helix | 120-129 | 10 | |
| α-helix | 133-143 | 11 | |
| β-strand | 144 | 1 | 3 |
| β-strand | 146 | 1 | 2 |
| α-helix | 147-149 | 3 | |
| α-helix | 150-159 | 10 | |
| β-strand | 167-171 | 5 | 4 |
| β-strand | 174-179 | 6 | 4 |
| α-helix | 182-189 | 8 | |
| α-helix | 192-197 | 6 | |
| β-strand | 198 | 1 | 5 |
| α-helix | 199-200 | 2 | |
| α-helix | 206-209 | 4 | |
| β-strand | 210 | 1 | 4 |
| β-strand | 268-271 | 4 | 4 |
| β-strand | 272 | 1 | 5 |
| α-helix | 278-286 | 9 | |
| β-strand | 292 | 1 | 4 |
| β-strand | 294-295 | 2 | 6 |
| β-strand | 310 | 1 | 7 |
| α-helix | 318-328 | 11 | |
| α-helix | 329-331 | 3 | |
| β-strand | 333-334 | 2 | 6 |
| β-strand | 336-339 | 4 | 8 |
| α-helix | 346-357 | 12 | |
| β-strand | 361-365 | 5 | 8 |
| α-helix | 368-381 | 14 | |
| β-strand | 382 | 1 | 7 |
| β-strand | 389-391 | 3 | 8 |
| β-strand | 405-409 | 5 | 8 |
| α-helix | 410-414 | 5 | |
| α-helix | 421-430 | 10 | |
| β-strand | 435-441 | 7 | 8 |
| α-helix | 443-445 | 3 | |
| α-helix | 454-457 | 4 | |
| β-strand | 460-467 | 8 | 8 |
| α-helix | 477-479 | 3 | |
| α-helix | 480-483 | 4 | |
| β-strand | 487-490 | 4 | 8 |
| α-helix | 493-497 | 5 | |
| β-strand | 505-512 | 8 | 9 |
| α-helix | 513-515 | 3 | |
| α-helix | 516-525 | 10 | |
| α-helix | 530-535 | 6 | |
| α-helix | 538-553 | 16 | |
| β-strand | 558-561 | 4 | 9 |
| α-helix | 565-575 | 11 | |
| β-strand | 579-580 | 2 | 9 |
| α-helix | 586-597 | 12 | |
| β-strand | 604-607 | 4 | 9 |
| β-strand | 622-625 | 4 | 9 |
| α-helix | 633-640 | 8 | |
| α-helix | 641-643 | 3 | |
| β-strand | 657-664 | 8 | 9 |
| α-helix | 668-671 | 4 | |
| α-helix | 678-683 | 6 | |
| β-strand | 687-690 | 4 | 9 |
| α-helix | 706-716 | 11 | |
| α-helix | 775-779 | 5 | |
Chain B: 39 helices, 25 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 2 | 1 | 10 |
| β-strand | 11 | 1 | 10 |
| β-strand | 16 | 1 | 11 |
| α-helix | 19-33 | 15 | |
| β-strand | 37-41 | 5 | 12 |
| α-helix | 49-62 | 14 | |
| β-strand | 69-74 | 6 | 12 |
| α-helix | 77-97 | 21 | |
| β-strand | 106-108 | 3 | 12 |
| α-helix | 127-138 | 12 | |
| α-helix | 140-148 | 9 | |
| α-helix | 156-163 | 8 | |
| β-strand | 174-175 | 2 | 12 |
| α-helix | 177-187 | 11 | |
| α-helix | 191-198 | 8 | |
| β-strand | 204-208 | 5 | 12 |
| α-helix | 210-213 | 4 | |
| β-strand | 229-234 | 6 | 12 |
| α-helix | 236-238 | 3 | |
| α-helix | 239-246 | 8 | |
| β-strand | 249-251 | 3 | 13 |
| α-helix | 253-273 | 21 | |
| α-helix | 278-290 | 13 | |
| α-helix | 297-300 | 4 | |
| α-helix | 318-320 | 3 | |
| α-helix | 326-344 | 19 | |
| β-strand | 350-352 | 3 | 13 |
| α-helix | 354-364 | 11 | |
| α-helix | 369-373 | 5 | |
| α-helix | 376-385 | 10 | |
| α-helix | 392-394 | 3 | |
| α-helix | 395-407 | 13 | |
| β-strand | 414-419 | 6 | 13 |
| β-strand | 432-437 | 6 | 13 |
| α-helix | 445-449 | 5 | |
| β-strand | 453-458 | 6 | 12 |
| α-helix | 466-471 | 6 | |
| β-strand | 475-480 | 6 | 12 |
| β-strand | 491-494 | 4 | 14 |
| β-strand | 497 | 1 | 15 |
| β-strand | 503 | 1 | 15 |
| α-helix | 510-512 | 3 | |
| α-helix | 514-530 | 17 | |
| β-strand | 535-539 | 5 | 14 |
| α-helix | 542-555 | 14 | |
| α-helix | 557-564 | 8 | |
| β-strand | 566-569 | 4 | 14 |
| α-helix | 575-589 | 15 | |
| β-strand | 594-599 | 6 | 14 |
| α-helix | 603-607 | 5 | |
| α-helix | 612-615 | 4 | |
| β-strand | 617-620 | 4 | 14 |
| α-helix | 631-642 | 12 | |
| α-helix | 648-664 | 17 | |
| β-strand | 676-679 | 4 | 14 |
| α-helix | 682-685 | 4 | |
| α-helix | 687-691 | 5 | |
| α-helix | 695-698 | 4 | |
| α-helix | 710-724 | 15 | |
| α-helix | 734-737 | 4 | |
| β-strand | 740 | 1 | 11 |
| α-helix | 741-744 | 4 | |
| α-helix | 747-754 | 8 | |
| β-strand | 758-759 | 2 | 12 |
Chain C: 20 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 116-120 | 5 | |
| α-helix | 122-128 | 7 | |
| α-helix | 129-133 | 5 | |
| α-helix | 139-142 | 4 | |
| α-helix | 170-173 | 4 | |
| β-strand | 186-188 | 3 | 16 |
| α-helix | 190-198 | 9 | |
| α-helix | 201-214 | 14 | |
| α-helix | 217-225 | 9 | |
| α-helix | 242-260 | 19 | |
| α-helix | 295-319 | 25 | |
| α-helix | 347-356 | 10 | |
| β-strand | 373 | 1 | 17 |
| α-helix | 381-384 | 4 | |
| α-helix | 398-412 | 15 | |
| α-helix | 424-433 | 10 | |
| α-helix | 458-476 | 19 | |
| α-helix | 479 | 1 | |
| α-helix | 481 | 1 | |
| α-helix | 484-503 | 20 | |
| α-helix | 510-515 | 6 | |
| α-helix | 523-545 | 23 | |
Chain D: 26 helices, 16 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 19-22 | 4 | |
| α-helix | 23-25 | 3 | |
| α-helix | 28-34 | 7 | |
| α-helix | 38-46 | 9 | |
| α-helix | 49 | 1 | |
| α-helix | 53-58 | 6 | |
| β-strand | 66-67 | 2 | 18 |
| α-helix | 77-79 | 3 | |
| α-helix | 80-92 | 13 | |
| β-strand | 96-99 | 4 | 18 |
| β-strand | 107-110 | 4 | 18 |
| α-helix | 112-122 | 11 | |
| α-helix | 133-135 | 3 | |
| α-helix | 145-163 | 19 | |
| α-helix | 173-182 | 10 | |
| β-strand | 185-186 | 2 | 19 |
| β-strand | 195-196 | 2 | 19 |
| α-helix | 198-203 | 6 | |
| α-helix | 208-221 | 14 | |
| α-helix | 224-226 | 3 | |
| α-helix | 230-241 | 12 | |
| β-strand | 249 | 1 | 20 |
| α-helix | 256-268 | 13 | |
| β-strand | 271-272 | 2 | 21 |
| β-strand | 281 | 1 | 20 |
| β-strand | 282-283 | 2 | 21 |
| α-helix | 285-288 | 4 | |
| β-strand | 307-309 | 3 | 1 |
| β-strand | 314-317 | 4 | 1 |
| α-helix | 322-328 | 7 | |
| α-helix | 329-331 | 3 | |
| β-strand | 333-337 | 5 | 1 |
| β-strand | 342-345 | 4 | 1 |
| α-helix | 348-355 | 8 | |
| α-helix | 364-370 | 7 | |
| α-helix | 374-376 | 3 | |
| α-helix | 385-395 | 11 | |
| β-strand | 402-409 | 8 | 22 |
| α-helix | 415-428 | 14 | |
| β-strand | 431-433 | 3 | 22 |
| β-strand | 442-443 | 2 | 22 |
| α-helix | 447-461 | 15 | |
Chain E: 18 helices, 21 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 18-21 | 4 | |
| β-strand | 53 | 1 | 17 |
| β-strand | 55 | 1 | 23 |
| β-strand | 59-66 | 8 | 24 |
| α-helix | 69-72 | 4 | |
| α-helix | 80-98 | 19 | |
| β-strand | 103-110 | 8 | 24 |
| β-strand | 113-121 | 9 | 24 |
| α-helix | 126-133 | 8 | |
| α-helix | 134-136 | 3 | |
| α-helix | 145-156 | 12 | |
| β-strand | 164-171 | 8 | 24 |
| α-helix | 182-191 | 10 | |
| β-strand | 195-200 | 6 | 24 |
| α-helix | 206-214 | 9 | |
| β-strand | 219-221 | 3 | 24 |
| α-helix | 225-234 | 10 | |
| α-helix | 238-239 | 2 | |
| β-strand | 240 | 1 | 23 |
| α-helix | 241-242 | 2 | |
| β-strand | 250-253 | 4 | 25 |
| β-strand | 270 | 1 | 26 |
| β-strand | 285 | 1 | 26 |
| β-strand | 289-290 | 2 | 27 |
| β-strand | 297-298 | 2 | 27 |
| β-strand | 303-304 | 2 | 25 |
| β-strand | 311-312 | 2 | 25 |
| α-helix | 315-318 | 4 | |
| α-helix | 319-321 | 3 | |
| α-helix | 322-325 | 4 | |
| α-helix | 329-331 | 3 | |
| β-strand | 332-335 | 4 | 28 |
| β-strand | 344 | 1 | 29 |
| β-strand | 351 | 1 | 29 |
| β-strand | 356-359 | 4 | 28 |
| β-strand | 367 | 1 | 28 |
| α-helix | 369-374 | 6 | |
| α-helix | 375-379 | 5 | |
| α-helix | 383-386 | 4 | |
Chain F: 10 helices, 12 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 8-16 | 9 | 30 |
| α-helix | 19-27 | 9 | |
| α-helix | 34-51 | 18 | |
| β-strand | 56-62 | 7 | 30 |
| β-strand | 67-71 | 5 | 30 |
| α-helix | 101 | 1 | |
| α-helix | 106-120 | 15 | |
| α-helix | 133-150 | 18 | |
| β-strand | 157-164 | 8 | 30 |
| α-helix | 174-186 | 13 | |
| β-strand | 190-195 | 6 | 30 |
| α-helix | 201-210 | 10 | |
| β-strand | 214-216 | 3 | 30 |
| α-helix | 224-226 | 3 | |
| α-helix | 227-231 | 5 | |
| α-helix | 235-239 | 5 | |
| β-strand | 254 | 1 | 31 |
| β-strand | 261 | 1 | 31 |
| β-strand | 264-267 | 4 | 25 |
| β-strand | 275 | 1 | 25 |
| β-strand | 281 | 1 | 32 |
| β-strand | 288 | 1 | 32 |
Chain G: 2 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 4-11 | 8 | 22 |
| α-helix | 14-26 | 13 | |
| β-strand | 36-37 | 2 | 22 |
| β-strand | 43-44 | 2 | 22 |
| α-helix | 50-61 | 12 | |
Chain H: 4 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 66-81 | 16 | |
| α-helix | 93-111 | 19 | |
| α-helix | 115-127 | 13 | |
| α-helix | 132-139 | 8 | |
3 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| General transcription and DNA repair factor IIH helicase subunit XPB | A | protein | 797 | Homo sapiens | P19447 (AlphaFold model) |
| TFIIH basal transcription factor complex helicase XPD subunit | B | protein | 771 | Homo sapiens | P18074 (AlphaFold model) |
| General transcription factor IIH subunit 1 | C | protein | 591 | Homo sapiens | P32780 (AlphaFold model) |
| General transcription factor IIH subunit 4 | D | protein | 462 | Homo sapiens | Q92759 (AlphaFold model) |
| General transcription factor IIH subunit 2 | E | protein | 395 | Homo sapiens | Q13888 |
| General transcription factor IIH subunit 3 | F | protein | 308 | Homo sapiens | Q13889 |
| General transcription factor IIH subunit 5 | G | protein | 71 | Homo sapiens | Q6ZYL4 |
| CDK-activating kinase assembly factor MAT1 | H | protein | 309 | Homo sapiens | P51948 |
| DNA repair protein complementing XP-C cells | I | protein | 940 | Homo sapiens | Q01831 |
| Lysine-specific demethylase RAD23B | J | protein | 409 | Homo sapiens | P54727 |
| Centrin-2 | K | protein | 172 | Homo sapiens | P41208 |
| DNA (Cy5) | L | DNA | 71 | synthetic construct | |
1 more molecules are not listed.
Sequence of entity 1 (A), FASTA
>28JS_1 General transcription and DNA repair factor IIH helicase subunit XPB (chains A)
HHHHHHENLYFQSNAMGKRDRADRDKKKSRKRHYEDEEDDEEDAPGNDPQEAVPSAAGKQ
VDESGTKVDEYGAKDYRLQMPLKDDHTSRPLWVAPDGHIFLEAFSPVYKYAQDFLVAIAE
PVCRPTHVHEYKLTAYSLYAAVSVGLQTSDITEYLRKLSKTGVPDGIMQFIKLCTVSYGK
VKLVLKHNRYFVESCHPDVIQHLLQDPVIRECRLRNSEGEATELITETFTSKSAISKTAE
SSGGPSTSRVTDPQGKSDIPMDLFDFYEQMDKDEEEEEETQTVSFEVKQEMIEELQKRCI
HLEYPLLAEYDFRNDSVNPDINIDLKPTAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAG
KSLVGVTAACTVRKRCLVLGNSAVSVEQWKAQFKMWSTIDDSQICRFTSDAKDKPIGCSV
AISTYSMLGHTTKRSWEAERVMEWLKTQEWGLMILDEVHTIPAKMFRRVLTIVQAHCKLG
LTATLVREDDKIVDLNFLIGPKLYEANWMELQNNGYIAKVQCAEVWCPMSPEFYREYVAI
KTKKRILLYTMNPNKFRACQFLIKFHERRNDKIIVFADNVFALKEYAIRLNKPYIYGPTS
QGERMQILQNFKHNPKINTIFISKVGDTSFDLPEANVLIQISSHGGSRRQEAQRLGRVLR
AKKGMVAEEYNAFFYSLVSQDTQEMAYSTKRQRFLVDQGYSFKVITKLAGMEEEDLAFST
KEEQQQLLQKVLAATDLDAEEEVVAGEFGSRSSQASRRFGTMSSMSGADDTVYMEYHSSR
SKAPSKHVHPLFKRFRK
Sequence of entity 2 (B), FASTA
>28JS_2 TFIIH basal transcription factor complex helicase XPD subunit (chains B)
MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQ
RAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPE
VTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDL
KALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNID
NVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARE
TDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSG
LAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEP
FDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMAT
FTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFT
SYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVA
RGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHA
AQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYF
LRQMAQPFHREDQLGLSLLSLEQLESEETLKRIEQIAQQLSSNDYKDDDDK
Sequence of entity 3 (C), FASTA
>28JS_3 General transcription factor IIH subunit 1 (chains C)
MATSSEEVLLIVKKVRQKKQDGALYLMAERIAWAPEGKDRFTISHMYADIKCQKISPEGK
AKIQLQLVLHAGDTTNFHFSNESTAVKERDAVKDLLQQLLPKFKRKANKELEEKNRMLQE
DPVLFQLYKDLVVSQVISAEEFWANRLNVNATDSSSTSNHKQDVGISAAFLADVRPQTDG
CNGLRYNLTSDIIESIFRTYPAVKMKYAENVPHNMTEKEFWTRFFQSHYFHRDRLNTGSK
DLFAECAKIDEKGLKTMVSLGVKNPLLDLTALEDKPLDEGYGISSVPSASNSKSIKENSN
AAIIKRFNHHSAMVLAAGLRKQEAQNEQTSEPSNMDGNSGDADCFQPAVKRAKLQESIEY
EDLGKNNSVKTIALNLKKSDRYYHGPTPIQSLQYATSQDIINSFQSIRQEMEAYTPKLTQ
VLSSSAASSTITALSPGGALMQGGTQQAINQMVPNDIQSELKHLYVAVGELLRHFWSCFP
VNTPFLEEKVVKMKSNLERFQVTKLCPFQEKIRRQYLSTNLVSHIEEMLQTAYNKLHTWQ
SRRLMKKTGSGGENLYFQSGSWSHPQFEKGGGSGGGSGGGSWSHPQFEKSG
Sequence of entity 4 (D), FASTA
>28JS_4 General transcription factor IIH subunit 4 (chains D)
MESTPSRGLNRVHLQCRNLQEFLGGLSPGVLDRLYGHPATCLAVFRELPSLAKNWVMRML
FLEQPLPQAAVALWVKKEFSKAQEESTGLLSGLRIWHTQLLPGGLQGLILNPIFRQNLRI
ALLGGGKAWSDDTSQLGPDKHARDVPSLDKYAEERWEVVLHFMVGSPSAAVSQDLAQLLS
QAGLMKSTEPGEPPCITSAGFQFLLLDTPAQLWYFMLQYLQTAQSRGMDLVEILSFLFQL
SFSTLGKDYSVEGMSDSLLNFLQHLREFGLVFQRKRKSRRYYPTRLAINLSSGVSGAGGT
VHQPGFIVVETNYRLYAYTESELQIALIALFSEMLYRFPNMVVAQVTRESVQQAIASGIT
AQQIIHFLRTRAHPVMLKQTPVLPPTITDQIRLWELERDRLRFTEGVLYNQFLSQVDFEL
LLAHARELGVLVFENSAKRLMVVTPAGHSDVKRFWKRQKHSS
Sequence of entity 5 (E), FASTA
>28JS_5 General transcription factor IIH subunit 2 (chains E)
MDEEPERTKRWEGGYERTWEILKEDESGSLKATIEDILFKAKRKRVFEHHGQVRLGMMRH
LYVVVDGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNPISQIGIIVTKSKRAEKLTEL
SGNPRKHITSLKKAVDMTCHGEPSLYNSLSIAMQTLKHMPGHTSREVLIIFSSLTTCDPS
NIYDLIKTLKAAKIRVSVIGLSAEVRVCTVLARETGGTYHVILDESHYKELLTHHVSPPP
ASSSSECSLIRMGFPQHTIASLSDQDAKPSFSMAHLDGNTEPGLTLGGYFCPQCRAKYCE
LPVECKICGLTLVSAPHLARSYHHLFPLDAFQEIPLEEYNGERFCYGCQGELKDQHVYVC
AVCQNVFCVDCDVFVHDSLHCCPGCIHKIPAPSGV
Sequence of entity 6 (F), FASTA
>28JS_6 General transcription factor IIH subunit 3 (chains F)
MVSDEDELNLLVIVVDANPIWWGKQALKESQFTLSKCIDAVMVLGNSHLFMNRSNKLAVI
ASHIQESRFLYPGKNGRLGDFFGDPGNPPEFNPSGSKDGKYELLTSANEVIVEEIKDLMT
KSDIKGQHTETLLAGSLAKALCYIHRMNKEVKDNQEMKSRILVIKAAEDSALQYMNFMNV
IFAAQKQNILIDACVLDSDSGLLQQACDITGGLYLKVPQMPSLLQYLLWVFLPDQDQRSQ
LILPPPVHVDYRAACFCHRNLIEIGYVCSVCLSIFCNFSPICTTCETAFKISLPPVLKAK
KKKLKVSA
Sequence of entity 7 (G), FASTA
>28JS_7 General transcription factor IIH subunit 5 (chains G)
MVNVLKGVLIECDPAMKQFLLYLDESNALGKKFIIQDIDDTHVFVIAELVNVLQERVGEL
MDQNAFSLTQK
Sequence of entity 8 (H), FASTA
>28JS_8 CDK-activating kinase assembly factor MAT1 (chains H)
MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECGTPLRKSNFRV
QLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEVEEIVFNLTNNVDLDNTKK
KMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQENEQRRLFIQKEEQLQQILKRKNK
QAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPKPVKPVTFSTGIKMGQHISLAPIHK
LEEALYEYQPLQIETYGPHVPELEMLGRLGYLNHVRAASPQDLAGGYTSSLACHRALQDA
FSGLFWQPS
Sequence of entity 9 (I), FASTA
>28JS_9 DNA repair protein complementing XP-C cells (chains I)
MARKRAAGGEPRGRELRSQKSKAKSKARREEEEEDAFEDEKPPKKSLLSKVSQGKRKRGC
SHPGGSADGPAKKKVAKVTVKSENLKVIKDEALSDGDDLRDFPSDLKKAHHLKRGATMNE
DSNEEEEESENDWEEVEELSEPVLGDVRESTAFSRSLLPVKPVEIEIETPEQAKTRERSE
KIKLEFETYLRRAMKRFNKGVHEDTHKVHLLCLLANGFYRNNICSQPDLHAIGLSIIPAR
FTRVLPRDVDTYYLSNLVKWFIGTFTVNAELSASEQDNLQTTLERRFAIYSARDDEELVH
IFLLILRALQLLTRLVLSLQPIPLKSATAKGKKPSKERLTADPGGSSETSSQVLENHTKP
KTSKGTKQEETFAKGTCRPSAKGKRNKGGRKKRSKPSSSEEDEGPGDKQEKATQRRPHGR
ERRVASRVSYKEESGSDEAGSGSDFELSSGEASDPSDEDSEPGPPKQRKAPAPQRTKAGS
KSASRTHRGSHRKDPSLPAASSSSSSSKRGKKMCSDGEKAEKRSIAGIDQWLEVFCEQEE
KWVCVDCVHGVVGQPLTCYKYATKPMTYVVGIDSDGWVRDVTQRYDPVWMTVTRKCRVDA
EWWAETLRPYQSPFMDREKKEDLEFQAKHMDQPLPTAIGLYKNHPLYALKRHLLKYEAIY
PETAAILGYCRGEAVYSRDCVHTLHSRDTWLKKARVVRLGEVPYKMVKGFSNRARKARLA
EPQLREENDLGLFGYWQTEEYQPPVAVDGKVPRNEFGNVYLFLPSMMPIGCVQLNLPNLH
RVARKLDIDCVQAITGFDFHGGYSHPVTDGYIVCEEFKDVLLTAWENEQAVIERKEKEKK
EKRALGNWKLLAKGLLIRERLKRRYGPKSEAAAPHTDAGGGLSSDEEEGTSSQAEAARIL
AASWPQNREDEEKQKLKGGPKKTKREKKAAASHLFPFEQL
Sequence of entity 10 (J), FASTA
>28JS_10 Lysine-specific demethylase RAD23B (chains J)
MQVTLKTLQQQTFKIDIDPEETVKALKEKIESEKGKDAFPVAGQKLIYAGKILNDDTALK
EYKIDEKNFVVVMVTKPKAVSTPAPATTQQSAPASTTAVTSSTTTTVAQAPTPVPALAPT
STPASITPASATASSEPAPASAAKQEKPAEKPAETPVATSPTATDSTSGDSSRSNLFEDA
TSALVTGQSYENMVTEIMSMGYEREQVIAALRASFNNPDRAVEYLLMGIPGDRESQAVVD
PPQAASTGAPQSSAVAAAAATTTATTTTTSSGGHPLEFLRNQPQFQQMRQIIQQNPSLLP
ALLQQIGRENPQLLQQISQHQEHFIQMLNEPVQEAGGQGGGGGGGSGGIAEAGSGHMNYI
QVTPQEKEAIERLKALGFPEGLVIQAYFACEKNENLAANFLLQQNFDED
Sequence of entity 11 (K), FASTA
>28JS_11 Centrin-2 (chains K)
MASNFKKANMASSSQRKRMSPKPELTEEQKQEIREAFDLFDADGTGTIDVKELKVAMRAL
GFEPKKEEIKKMISEIDKEGTGKMNFGDFLTVMTQKMSEKDTKEEILKAFKLFDDDETGK
ISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEVSEQEFLRIMKKTSLY
Sequence of entity 12 (L), FASTA
>28JS_12 DNA (Cy5) (chains L)
CCATCCCTATACCTATACCCATTCCAACCATCCCACTACCXTCCATCTTCACTCAACTAT
CACCCTAATAC
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| CA | Calcium ion | Ca | 2 |
| ZN | Zinc ion | Zn | 5 |
| SF4 | Iron/sulfur cluster | Fe4 S4 | 1 |
Primary citation
Visualization of stepwise derepression of TFIIH in global genome nucleotide excision repair. de Martin Garrido, N., Haste, C.A.F., Feng, J. et al. Sci Adv (2026) 12:eaeb3506-eaeb3506. DOI 10.1126/sciadv.aeb3506 · PubMed
Other PDB entries of the same protein (UniProt P19447 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 4ERN 1.8 Å, Crystal structure of the C-terminal domain of human XPB/ERCC-3 excision repair protein…
- 7NVV 2.9 Å, XPB-containing part of TFIIH in a post-translocated state (with ADP-BeF3)
- 28JM 3.29 Å, Cryo-EM structure of the human holo-TFIIH and XPC initial encounter complex
- 7EGB 3.3 Å, TFIID-based holo PIC on SCP promoter
- 8EBU 3.3 Å, XPC release from Core7-XPA-DNA (Cy5)
- 9PD3 3.3 Å, NER dual incision complex - DuIS
- 9PD4 3.4 Å, NER dual incision complex - DuIM
- 6RO4 3.5 Å, Structure of the core TFIIH-XPA-DNA complex
- 7AD8 3.5 Å, Core TFIIH-XPA-DNA complex with modelled p62 subunit
- 9XYU 3.5 Å, NER complex - C7CAD.ATP
- 28KE 3.6 Å, Cryo-EM structure of the human holo-TFIIH-XPC-XPA complex bound to bulky lesion-mimic DNA
- 8EBX 3.6 Å, XPA repositioning Core7 of TFIIH relative to XPC-DNA lesion (AP)
Browse structure collections
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