29UT: KAT8 mutant

KAT8 mutant (KAT6A surrogate, myst-cryst) in complex with KAT6A inhibitor compound 2. Determined by X-ray diffraction at 1.4 Å resolution. Released 9 Sept 2026.

Method: X-ray diffraction
Resolution: 1.4 Å
Organism: Homo sapiens
Chains: 1
Atoms: 2,734
Mol. weight: 33.45 kDa
Ligands: A1J4V, ZN
Released: 9 Sept 2026

Explore 29UT in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

29UT contains 13 α-helices and 16 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain AAA: 13 helices, 16 β-strands

Element	Residues	Length	Sheet
β-strand	511-514	4	1
β-strand	517-520	4	1
α-helix	529-532	4
β-strand	537-539	3	1
β-strand	546-547	2	1
α-helix	550-559	10
β-strand	568-573	6	2
β-strand	576-582	7	2
α-helix	587-598	12
β-strand	613-622	10	2
β-strand	625-635	11	2
β-strand	642-644	3	3
β-strand	647-649	3	2
α-helix	651-653	3
α-helix	658-672	15
β-strand	677	1	4
β-strand	678-679	2	3
α-helix	680	1
α-helix	683-684	2
α-helix	685-705	21
α-helix	712-719	8
β-strand	721	1	4
α-helix	723-732	10
β-strand	736-739	4	5
β-strand	742-745	4	5
α-helix	749-757	9
α-helix	759-761	3
α-helix	770-772	3
β-strand	773	1	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Histone acetyltransferase KAT8	AAA	protein	278	Homo sapiens	Q9H7Z6 (AlphaFold model)

Sequence of entity 1 (AAA), FASTA

>29UT_1 Histone acetyltransferase KAT8 (chains AAA)
GSTKVKYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKYEKSYRFHLGQCQ
WRQPPGKEIYRKSNISVHEVDGKDHKIYCQNLCLLAKLFLDHKTLYFDVEPFVFYILTEV
DRQGAHIVGYFSKEKESPDGNNVSCIMILPPYQRRGYGRFLIAFSYELSKLESTVGSPEK
PLSDLGKLSYRSYWSSVLLENLRDFRGTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKG
QHVICVTPKLVEEHLKSAQYKKPPITVDSVCLKWAPPK

Ligands and cofactors

ID	Name	Formula	Copies
A1J4V	6-(dimethylamino)-N-(2-methylquinolin-8-yl)sulfonyl-4-(trifluoromethyl)-1-benzo…	C22 H18 F3 N3 O4 S	1
ZN	Zinc ion	Zn	1

Water and common crystallization additives (CL, GOL) are not listed.

Primary citation

KAT6A-inhibitor co-crystal structures: tackling a challenging crystallization target via two alternative approaches. Puetter, V., Bouche, L., Nowak-Reppel, K. et al. Acta Crystallogr D Struct Biol (2026) 82:1111-1124. DOI 10.1107/S2059798326008545 · PubMed

Other PDB entries of the same protein (UniProt Q9H7Z6 (AlphaFold model), which also has an AlphaFold model), best resolution first:

29UU 1.3 Å, KAT8 mutant (KAT6A surrogate, myst-cryst) in complex with KAT6A inhibitor example-41
9OOA 1.39 Å, Crystal structure of MYST acetyltransferase domain in complex with inhibitor 7
2PQ8 1.45 Å, MYST histone acetyltransferase 1
9OOF 1.68 Å, Crystal structure of MYST acetyltransferase domain in complex with inhibitor 10e
29TM 1.7 Å, KAT8 mutant (KAT6A surrogate, myst-cryst) in complex with KAT6A inhibitor bay-7728
6OIN 1.7 Å, Crystal structure of MYST acetyltransferase domain in complex with inhibitor CTX-124143
6OIO 1.7 Å, Crystal structure of MYST acetyltransferase domain in complex with inhibitor 60
6OIQ 1.75 Å, Crystal structure of MYST acetyltransferase domain in complex with inhibitor 63
6OWI 1.75 Å, Crystal structure of MYST acetyltransferase domain in complex with inhibitor 85
5WCI 1.78 Å, Human MYST histone acetyltransferase 1
29TN 1.8 Å, KAT8 mutant (KAT6A surrogate, myst-cryst) in complex with KAT6A inhibitor compound 38
6OIP 1.8 Å, Crystal structure of MYST acetyltransferase domain in complex with inhibitor 34

Browse structure collections

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