2AA2: Mineralocorticoid receptor

Mineralocorticoid Receptor with Bound Aldosterone. Determined by X-ray diffraction at 1.95 Å resolution. Released 26 Jul 2005.

Method: X-ray diffraction
Resolution: 1.95 Å
Organism: Homo sapiens
Chains: 1
Atoms: 2,227
Mol. weight: 32.54 kDa
Ligands: BOG, AS4
Released: 26 Jul 2005

Explore 2AA2 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2AA2 contains 13 α-helices and 4 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 13 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	729-734	6
α-helix	736-737	2
α-helix	738-745	8
α-helix	747-751	5
α-helix	762-785	24
α-helix	795-822	28
β-strand	827-830	4	1
β-strand	833-835	3	1
α-helix	837-842	6
α-helix	846-862	17
α-helix	866-877	12
β-strand	880-882	3	2
α-helix	889-907	19
α-helix	917-947	31
α-helix	949-952	4
α-helix	958-972	15
β-strand	976-978	3	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Mineralocorticoid receptor	A	protein	275	Homo sapiens	P08235 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2AA2_1 Mineralocorticoid receptor (chains A)
GSAPAKEPSVNTALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTL
NRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMSLSSFALSWRSYKHTNSQFLYF
APDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQ
AAFEEMRTNYIKELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRES
HALKVEFPAMLVEIISDQLPKVESGNAKPLYFHRK

Ligands and cofactors

ID	Name	Formula	Copies
BOG	octyl beta-D-glucopyranoside	C14 H28 O6	1
AS4	Aldosterone	C21 H28 O5	1

Water and common crystallization additives (SO4, GOL) are not listed.

Primary citation

A Ligand-mediated Hydrogen Bond Network Required for the Activation of the Mineralocorticoid Receptor. Bledsoe, R.K., Madauss, K.P., Holt, J.A. et al. J Biol Chem (2005) 280:31283-31293. DOI 10.1074/jbc.M504098200 · PubMed

Other PDB entries of the same protein (UniProt P08235 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4PF3 1.1 Å, Mineralocorticoid receptor ligand-binding domain with compuond 37a
3VHV 1.35 Å, Mineralocorticoid receptor ligand-binding domain with non-steroidal antagonist
3WFG 1.4 Å, Mineralocorticoid receptor ligand-binding domain with compuond 2e
9GC7 1.46 Å, Mineralocorticoid receptor in complex with acylurea antagonists.
6GEV 1.54 Å, Mineralocorticoid receptor in complex with (s)-13
6GGG 1.71 Å, Mineralocorticoid receptor in complex with (s)-13
2AAX 1.75 Å, Mineralocorticoid Receptor Double Mutant with Bound Cortisone
5MWY 1.75 Å, The structure of MR in complex with eplerenone.
6GG8 1.8 Å, Mineralocorticoid receptor in complex with (s)-13
5MWP 1.82 Å, The structure of MR in complex with AZD9977.
5L7H 1.84 Å, MCR IN COMPLEX WITH ligand
2AB2 1.85 Å, Mineralocorticoid Receptor Double Mutant with Bound Spironolactone

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