Mineralocorticoid receptor (NR3C2) is a 984-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P08235.
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The mean pLDDT of this model is 55.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 28% |
| 70 to 90 | Confident: backbone generally right | 6% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 63% |
What pLDDT means and how to read it
Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels
Heteromultimeric cytoplasmic complex with HSP90, HSP70, and FKBP4, in the absence of ligand. After ligand binding, it translocates to the nucleus and binds to DNA as a homodimer and as a heterodimer with NR3C1. May interact with HSD11B2 in the absence of ligand. Binds the coactivators NCOA1, NCOA2, TIF1 and NRIP1
Cytoplasm, Nucleus, Endoplasmic reticulum membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4PF3 | X-ray | 1.1 Å | A=712-984 |
| 3VHV | X-ray | 1.35 Å | A=727-984 |
| 3WFG | X-ray | 1.4 Å | A=712-984 |
| 9GC7 | X-ray | 1.46 Å | A=735-984 |
| 6GEV | X-ray | 1.54 Å | A=735-984 |
| 6GGG | X-ray | 1.71 Å | A=735-984 |
| 2AAX | X-ray | 1.75 Å | A/B=712-984 |
| 5MWY | X-ray | 1.75 Å | A=735-984 |
| 6GG8 | X-ray | 1.8 Å | A=735-984 |
| 5MWP | X-ray | 1.82 Å | A=735-984 |
| 5L7H | X-ray | 1.84 Å | A=735-984 |
| 2AB2 | X-ray | 1.85 Å | A/B=712-984 |
| 5L7E | X-ray | 1.86 Å | A=735-984 |
| 2A3I | X-ray | 1.95 Å | A=732-984 |
| 2AA2 | X-ray | 1.95 Å | A=712-984 |
| 2AA6 | X-ray | 1.95 Å | A/B=712-984 |
| 1Y9R | X-ray | 1.96 Å | A/B=731-984 |
| 5L7G | X-ray | 2.01 Å | A=735-984 |
| 4UDA | X-ray | 2.03 Å | A=735-984 |
| 3WFF | X-ray | 2.05 Å | A=712-984 |
Showing 20 of 30 experimental structures (best resolution first).
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