2AWW: Synapse associated protein 97

Synapse associated protein 97 PDZ2 domain variant C378G with C-terminal GluR-A peptide. Determined by X-ray diffraction at 2.21 Å resolution. Released 29 Aug 2006.

Method: X-ray diffraction
Resolution: 2.21 Å
Organism: Rattus norvegicus
Chains: 3
Atoms: 1,348
Mol. weight: 24.49 kDa
Released: 29 Aug 2006

Explore 2AWW in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2AWW contains 4 α-helices and 19 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 3 helices, 10 β-strands

Element	Residues	Length	Sheet
β-strand	319-323	5	1
β-strand	325	1	2
β-strand	328	1	2
β-strand	331-335	5	1
β-strand	342	1	3
β-strand	345	1	3
β-strand	348-353	6	1
α-helix	358-362	5
α-helix	369	1
β-strand	370-374	5	1
β-strand	377-378	2	1
α-helix	384-392	9
β-strand	397-403	7	1

Chain B: 1 helix, 8 β-strands

Element	Residues	Length	Sheet
β-strand	316-323	8	4
β-strand	332-335	4	4
β-strand	342	1	5
β-strand	345	1	5
β-strand	348-352	5	4
α-helix	358-361	4
β-strand	370-374	5	4
β-strand	377-378	2	4
β-strand	397-404	8	4

Chain C: 0 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	16-17	2	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Synapse associated protein 97	A, B	protein	105	Rattus norvegicus	Q62696 (AlphaFold model)
18-residue C-terminal peptide from glutamate receptor, ionotropic, AMPA1	C	protein	18		P19490 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>2AWW_1 Synapse associated protein 97 (chains A, B)
MEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTSIVEGGAAHKDGKLQIGDKLLA
VNSVGLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYISRHHHHHH

Sequence of entity 2 (C), FASTA

>2AWW_2 18-residue C-terminal peptide from glutamate receptor, ionotropic, AMPA1 (chains C)
SIPCMSHSSGMPLGATGL

Primary citation

Crystal structure of the second PDZ domain of SAP97 in complex with a GluR-A C-terminal peptide. von Ossowski, I., Oksanen, E., von Ossowski, L. et al. FEBS J (2006) 273:5219-5229. DOI 10.1111/j.1742-4658.2006.05521.x · PubMed

Other PDB entries of the same protein (UniProt Q62696 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2AWX 1.8 Å, Synapse associated protein 97 PDZ2 domain variant C378S
2I0L 2.31 Å, X-ray crystal structure of Sap97 PDZ2 bound to the C-terminal peptide of HPV18 E6.
2G2L 2.35 Å, Crystal Structure of the Second PDZ Domain of SAP97 in Complex with a GluR-A C-terminal…
2AWU 2.44 Å, Synapse associated protein 97 PDZ2 domain variant C378G
3UAT 2.7 Å, Guanylate Kinase Domains of the MAGUK Family Scaffold Proteins as Specific…
2I0I 2.8 Å, X-ray crystal structure of Sap97 PDZ3 bound to the C-terminal peptide of HPV18 E6
1RSO Hetero-tetrameric L27 (Lin-2, Lin-7) domain complexes as organization platforms of…
1ZOK PDZ1 Domain Of Synapse Associated Protein 97

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