2BH9: Glucose-6-phosphate 1-dehydrogenase

X-ray structure of a deletion variant of human glucose 6-phosphate dehydrogenase complexed with structural and coenzyme NADP. Determined by X-ray diffraction at 2.5 Å resolution. Released 25 Apr 2005.

Method: X-ray diffraction
Resolution: 2.5 Å
Organism: HOMO SAPIENS
Chains: 1
Atoms: 4,241
Mol. weight: 58.07 kDa
Ligands: NAP
Released: 25 Apr 2005

Explore 2BH9 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2BH9 contains 29 α-helices and 17 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 29 helices, 17 β-strands

Element	Residues	Length	Sheet
β-strand	32-37	6	1
α-helix	42-43	2
α-helix	44-48	5
α-helix	49-57	9
β-strand	65-71	7	1
α-helix	77-84	8
α-helix	85-87	3
α-helix	92-94	3
α-helix	95-103	9
β-strand	105-109	5	1
α-helix	115-126	12
β-strand	135-140	6	1
α-helix	147-157	11
β-strand	165-169	5	1
α-helix	177-187	11
α-helix	193-195	3
β-strand	196-198	3	1
α-helix	201-204	4
α-helix	206-216	11
α-helix	219-221	3
β-strand	230-238	9	2
α-helix	247-250	4
α-helix	254-255	2
α-helix	256-264	9
α-helix	265-272	8
α-helix	273-276	4
α-helix	281-292	12
β-strand	295	1	3
α-helix	296-299	4
α-helix	300-302	3
β-strand	303-309	7	2
α-helix	322-324	3
α-helix	329	1
β-strand	337-343	7	2
β-strand	344	1	3
β-strand	353-359	7	2
β-strand	366-373	8	2
α-helix	374-376	3
β-strand	389-395	7	2
β-strand	399-407	9	2
β-strand	415-423	9	2
α-helix	432-435	4
α-helix	436-446	11
α-helix	455-475	21
β-strand	480-483	4	2
α-helix	490-499	10

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Glucose-6-phosphate 1-dehydrogenase	A	protein	489	HOMO SAPIENS	P11413 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2BH9_1 GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (chains A)
VQSDTHIFIIMGASGDLAKKKIYPTIWWLFRDGLLPENTFIVGYARSRLTVADIRKQSEP
FFKATPEEKLKLEDFFARNSYVAGQYDDAASYQRLNSHMNALHLGSQANRLFYLALPPTV
YEAVTKNIHESCMSQIGWNRIIVEKPFGRDLQSSDRLSNHISSLFREDQIYRIDHYLGKE
MVQNLMVLRFANRIFGPIWNRDNIACVILTFKEPFGTEGRGGYFDEFGIIRDVMQNHLLQ
MLCLVAMEKPASTNSDDVRDEKVKVLKCISEVQANNVVLGQYVGNPDGEGEATKGYLDDP
TVPRGSTTATFAAVVLYVENERWDGVPFILRCGKALNERKAEVRLQFHDVAGDIFHQQCK
RNELVIRVQPNEAVYTKMMTKKPGMFFNPEESELDLTYGNRYKNVKLPDAYERLILDVFC
GSQMHFVRSDELREAWRIFTPLLHQIELEKPKPIPYIYGSRGPTEADELMKRVGFQYEGT
YKWVNPHKL

Ligands and cofactors

ID	Name	Formula	Copies
NAP	NADP nicotinamide-adenine-dinucleotide phosphate	C21 H28 N7 O17 P3	2

Water and common crystallization additives (GOL) are not listed.

Primary citation

Structural Studies of Glucose-6-Phosphate and Nadp+ Binding to Human Glucose-6-Phosphate Dehydrogenase. Kotaka, M., Gover, S., Vandeputte-Rutten, L. et al. Acta Crystallogr D Biol Crystallogr (2005) 61:495. DOI 10.1107/S0907444905002350 · PubMed

Other PDB entries of the same protein (UniProt P11413 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6JYU 1.89 Å, Crystal structure of Human G6PD Canton
6E08 1.9 Å, Crystal structure of G6PD in complex with structural NADP
7SNH 2.2 Å, Structure of G6PD-D200N tetramer bound to NADP+
7ZVE 2.28 Å, K403 acetylated glucose-6-phosphate dehydrogenase (G6PD)
7ZVD 2.46 Å, K89 acetylated glucose-6-phosphate dehydrogenase (G6PD) in a complex with structural NADP+
7SNI 2.5 Å, Structure of G6PD-D200N tetramer bound to NADP+ and G6P
7UC2 2.5 Å, Structure of G6PD-D200N tetramer bound to NADP+ with no symmetry applied
6E07 2.6 Å, Crystal structure of Canton G6PD in complex with structural NADP
5UKW 2.65 Å, Crystal structure of human Glucose 6-phosphate Dehydrogenase mutant (A277C) complexed…
7SNG 2.8 Å, structure of G6PD-WT tetramer
2BHL 2.9 Å, X-ray structure of human glucose-6-phosphate dehydrogenase (deletion variant) complexed…
7SEH 2.9 Å, Glucose-6-phosphate 1-dehydrogenase (K403QdLtL)

Browse structure collections

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