2BZ8: N-terminal Sh3 domain of CIN85

Name: PDB 2BZ8: N-terminal Sh3 domain of CIN85 bound to Cbl-b peptide
Published: 2005-10-05
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: sh3 domain

N-terminal Sh3 domain of CIN85 bound to Cbl-b peptide. Determined by X-ray diffraction at 2.0 Å resolution. Released 5 Oct 2005.

Method: X-ray diffraction
Resolution: 2.0 Å
Organism: HOMO SAPIENS
Chains: 3
Atoms: 1,109
Mol. weight: 14.92 kDa
Released: 5 Oct 2005

Explore 2BZ8 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2BZ8 contains 6 α-helices and 18 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 3 helices, 9 β-strands

Element	Residues	Length	Sheet
β-strand	4-6	3	1
β-strand	10	1	2
β-strand	17	1	3
α-helix	18-19	2
β-strand	20	1	2
α-helix	24	1
β-strand	25-26	2	1
β-strand	27-30	4	3
β-strand	36-41	6	3
β-strand	44-49	6	3
α-helix	50-52	3
β-strand	53-55	3	1

Chain B: 1 helix, 9 β-strands

Element	Residues	Length	Sheet
β-strand	4-6	3	4
β-strand	10	1	5
β-strand	17	1	6
β-strand	20	1	5
β-strand	25-26	2	4
β-strand	27-30	4	6
β-strand	36-40	5	6
β-strand	45-49	5	6
α-helix	50-52	3
β-strand	53-55	3	4

Chain C: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	903-906	4
α-helix	908-910	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
SH3-domain kinase binding protein 1	A, B	protein	58	HOMO SAPIENS	Q96B97 (AlphaFold model)
Signal transduction protein cbl-B SH3-binding protein cbl-B, ring finger protein 56, cbl-B	C	protein	11	HOMO SAPIENS	Q13191 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>2BZ8_1 SH3-DOMAIN KINASE BINDING PROTEIN 1 (chains A, B)
MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKK

Sequence of entity 2 (C), FASTA

>2BZ8_2 SIGNAL TRANSDUCTION PROTEIN CBL-B SH3-BINDING PROTEIN CBL-B, RING FINGER PROTEIN 56, CBL-B (chains C)
PARPPKPRPRR

Primary citation

Cbl Promotes Clustering of Endocytic Adaptor Proteins. Jozic, D., Cardenes, N., Lissanu-Deribe, Y. et al. Nat Struct Mol Biol (2005) 12:972. DOI 10.1038/NSMB1000 · PubMed

Other PDB entries of the same protein (UniProt Q96B97 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5ABS 1.74 Å, Crystal structure of the C-terminal coiled-coil domain of CIN85 in space group P321
2YDL 2.05 Å, Crystal structure of SH3C from CIN85
2K6D CIN85 Sh3-C domain in complex with ubiquitin
2K9G Solution structure of the third SH3 domain of the Cin85 adapter protein
2N64 NMR Structure of the C-terminal Coiled-Coil Domain of CIN85
2O2O Solution structure of domain B from human CIN85 PROTEIN

Browse structure collections

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