2F2X: Alpha-spectrin SH3 domain R21G mutant

alpha-spectrin SH3 domain R21G mutant. Determined by X-ray diffraction at 1.6 Å resolution. Released 31 Oct 2006.

Method: X-ray diffraction
Resolution: 1.6 Å
Organism: Gallus gallus
Chains: 1
Atoms: 536
Mol. weight: 7.23 kDa
Released: 31 Oct 2006

Explore 2F2X in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2F2X contains 1 α-helix and 8 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 1 helix, 8 β-strands

Element	Residues	Length	Sheet
β-strand	8-11	4	1
β-strand	15	1	2
β-strand	22	1	1
β-strand	25	1	2
β-strand	30-35	6	1
β-strand	41-46	6	1
β-strand	49-54	6	1
α-helix	55-57	3
β-strand	58-60	3	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Spectrin alpha chain, brain	A	protein	62	Gallus gallus	P07751 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2F2X_1 Spectrin alpha chain, brain (chains A)
MDETGKELVLALYDYQEKSPGEVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKK
LD

Primary citation

Cooperative propagation of local stability changes from low-stability and high-stability regions in a SH3 domain. Casares, S., Lopez-Mayorga, O., Vega, M.C. et al. Proteins (2007) 67:531-547. DOI 10.1002/prot.21284 · PubMed

Other PDB entries of the same protein (UniProt P07751 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9IHA 1.01 Å, A-spectrin SH3 domain V9L, A11V, M25V, V46F, V58L mutant
9EYC 1.06 Å, A-spectrin SH3 domain V9L, A11V, V23L, M25C, V46W, V53L and V58L mutant
3NGP 1.08 Å, High resolution structure of alpha-spectrin SH3 domain mutant with a redesigned core
3M0R 1.1 Å, Crystal Structure of the R21D mutant of alpha-spectrin SH3 domain. Crystal obtained in…
3M0U 1.1 Å, Crystal Structure of the R21D mutant of alpha-spectrin SH3 domain. Hexagonal crystal…
1G2B 1.12 Å, Alpha-spectrin src homology 3 domain, circular permutant, cut at N47-D48
9IH7 1.12 Å, A-spectrin SH3 domain V9L, A11V, V23I, M25V, V46F, V53L, V58L mutant
9EYE 1.13 Å, A-spectrin SH3 domain V9L, A11V, L31V, V44I, V53I mutant
9IH6 1.31 Å, A-spectrin SH3 domain V9Y, A11V, V23L, M25V, V53L, V58L mutant
9EYB 1.34 Å, A-spectrin SH3 domain V9L, A11V, V23L, M25C, V46W, V53L and V58L mutant
9EYF 1.34 Å, A-spectrin SH3 domain V9L, A11V, V23L, M25L, V46Y, V53I mutant
5IHK 1.35 Å, Crystal Structure of the alpha spectrin SH3 domain mutant N47A

Browse structure collections

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