9EYE: Spectrin alpha chain, non-erythrocytic 1

A-spectrin SH3 domain V9L, A11V, L31V, V44I, V53I mutant. Determined by X-ray diffraction at 1.13 Å resolution. Released 6 Aug 2025.

Method: X-ray diffraction
Resolution: 1.13 Å
Organism: Gallus gallus
Chains: 1
Atoms: 630
Mol. weight: 7.57 kDa
Ligands: PO4
Released: 6 Aug 2025

Explore 9EYE in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9EYE contains 2 α-helices and 8 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain AAA: 2 helices, 8 β-strands

Element	Residues	Length	Sheet
α-helix	6-7	2
β-strand	8-11	4	1
β-strand	15	1	2
β-strand	22	1	1
β-strand	25	1	2
β-strand	30-35	6	1
β-strand	41-46	6	1
β-strand	49-54	6	1
α-helix	55-57	3
β-strand	58-60	3	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Spectrin alpha chain, non-erythrocytic 1	AAA	protein	62	Gallus gallus	P07751 (AlphaFold model)

Sequence of entity 1 (AAA), FASTA

>9EYE_1 Spectrin alpha chain, non-erythrocytic 1 (chains AAA)
MDETGKELLLVLYDYQEKSPREVTMKKGDIVTLLNSTNKDWWKIEVNDRQGFIPAAYVKK
LD

Ligands and cofactors

ID	Name	Formula	Copies
PO4	Phosphate ion	O4 P	2

Water and common crystallization additives (GOL) are not listed.

Primary citation

Artificial intelligence and first-principle methods in protein redesign: A marriage of convenience? Cianferoni, D., Vizarraga, D., Fernandez-Escamilla, A.M. et al. Protein Sci (2025) 34:e70210-e70210. DOI 10.1002/pro.70210 · PubMed

Other PDB entries of the same protein (UniProt P07751 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9IHA 1.01 Å, A-spectrin SH3 domain V9L, A11V, M25V, V46F, V58L mutant
9EYC 1.06 Å, A-spectrin SH3 domain V9L, A11V, V23L, M25C, V46W, V53L and V58L mutant
3NGP 1.08 Å, High resolution structure of alpha-spectrin SH3 domain mutant with a redesigned core
3M0R 1.1 Å, Crystal Structure of the R21D mutant of alpha-spectrin SH3 domain. Crystal obtained in…
3M0U 1.1 Å, Crystal Structure of the R21D mutant of alpha-spectrin SH3 domain. Hexagonal crystal…
1G2B 1.12 Å, Alpha-spectrin src homology 3 domain, circular permutant, cut at N47-D48
9IH7 1.12 Å, A-spectrin SH3 domain V9L, A11V, V23I, M25V, V46F, V53L, V58L mutant
9IH6 1.31 Å, A-spectrin SH3 domain V9Y, A11V, V23L, M25V, V53L, V58L mutant
9EYB 1.34 Å, A-spectrin SH3 domain V9L, A11V, V23L, M25C, V46W, V53L and V58L mutant
9EYF 1.34 Å, A-spectrin SH3 domain V9L, A11V, V23L, M25L, V46Y, V53I mutant
5IHK 1.35 Å, Crystal Structure of the alpha spectrin SH3 domain mutant N47A
3I9Q 1.45 Å, Crystal Structure of the triple mutant S19G-P20D-R21S of alpha spectrin SH3 domain

Browse structure collections

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