2FH1: Gelsolin

C-terminal half of gelsolin soaked in low calcium at pH 4.5. Determined by X-ray diffraction at 1.55 Å resolution. Released 13 Jun 2006.

Method: X-ray diffraction
Resolution: 1.55 Å
Organism: Homo sapiens
Chains: 3
Atoms: 8,675
Mol. weight: 113.65 kDa
Ligands: CA
Released: 13 Jun 2006

Explore 2FH1 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2FH1 contains 48 α-helices and 57 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 15 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	419-426	8	1
β-strand	429-432	4	1
α-helix	433-434	2
α-helix	435-437	3
β-strand	440-442	3	2
β-strand	446-455	10	1
β-strand	458-467	10	1
α-helix	473-489	17
β-strand	495-500	6	1
α-helix	506-509	4
α-helix	510-512	3
α-helix	515-516	2
β-strand	517-520	4	2
α-helix	531-534	4
β-strand	537-543	7	2
β-strand	549-554	6	2
α-helix	558-560	3
β-strand	562	1	3
β-strand	566-570	5	2
β-strand	575-579	5	2
α-helix	585-597	13
α-helix	601-602	2
β-strand	603-606	4	2
α-helix	612-617	6
β-strand	625	1	3
α-helix	628-631	4
β-strand	641-646	6	4
β-strand	653-657	5	4
α-helix	663-665	3
β-strand	671-675	5	4
β-strand	680-684	5	4
α-helix	690-705	16
β-strand	717-721	5	4
α-helix	727-730	4

Chain B: 16 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	420-426	7	5
β-strand	429-432	4	5
α-helix	433-434	2
α-helix	435-437	3
β-strand	440-442	3	6
β-strand	446-452	7	5
β-strand	461-467	7	5
α-helix	473-489	17
β-strand	495-500	6	5
α-helix	506-509	4
α-helix	510-512	3
α-helix	515-516	2
β-strand	517-520	4	6
α-helix	530-534	5
β-strand	537-543	7	6
β-strand	549-554	6	6
α-helix	558-560	3
β-strand	562	1	7
β-strand	566-570	5	6
β-strand	575-579	5	6
α-helix	585-597	13
α-helix	601-602	2
β-strand	603-606	4	6
α-helix	612-617	6
β-strand	625	1	7
α-helix	628-631	4
β-strand	641-646	6	8
β-strand	653-656	4	8
α-helix	657-658	2
α-helix	663-665	3
β-strand	671-675	5	8
β-strand	680-684	5	8
α-helix	690-705	16
β-strand	717-721	5	8
α-helix	727-730	4

Chain C: 17 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	420-426	7	9
β-strand	429-432	4	9
α-helix	433-434	2
α-helix	435-437	3
β-strand	440-442	3	10
β-strand	446-452	7	9
β-strand	461-467	7	9
α-helix	473-489	17
β-strand	495-500	6	9
α-helix	506-509	4
α-helix	510-512	3
α-helix	515-516	2
β-strand	517-520	4	10
α-helix	531-534	4
β-strand	537-543	7	10
β-strand	549-554	6	10
α-helix	558-560	3
β-strand	562	1	11
β-strand	566-570	5	10
β-strand	575-579	5	10
α-helix	585-598	14
α-helix	601-602	2
β-strand	603-606	4	10
α-helix	612-617	6
β-strand	625	1	11
α-helix	628-631	4
β-strand	641-646	6	12
β-strand	653-657	5	12
α-helix	658	1
α-helix	663-665	3
β-strand	671-675	5	12
β-strand	680-684	5	12
α-helix	690-706	17
α-helix	708-710	3
β-strand	717-721	5	12
α-helix	727-730	4

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Gelsolin	A, B, C	protein	344	Homo sapiens	P06396 (AlphaFold model)

Sequence of entity 1 (A, B, C), FASTA

>2FH1_1 Gelsolin (chains A, B, C)
MDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYNYRHGGRQGQIIYNWQGAQS
TQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQT
APASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTPSAAYLWVGTGASEAEKTGA
QELLRVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLKDKKMDAHPPRLFACSNKIGR
FVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDPANR
DRRTPITVVKQGFEPPSFVGWFLGWDDDYWSVDPLDRAMAELAA

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	9

Primary citation

Calcium ion exchange in crystalline gelsolin. Chumnarnsilpa, S., Loonchanta, A., Xue, B. et al. J Mol Biol (2006) 357:773-782. DOI 10.1016/j.jmb.2006.01.026 · PubMed

Other PDB entries of the same protein (UniProt P06396 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5FAF 1.05 Å, N184K pathological variant of gelsolin domain 2 (orthorhombic form)
6QW3 1.3 Å, Calcium-bound gelsolin domain 2
6LJE 1.4 Å, Crystal structure of gelsolin G3 domain (calcium and magnesium condition)
6LJF 1.5 Å, Crystal structure of gelsolin G3 domain (calcium condition)
3CIP 1.6 Å, Complex of Dictyostelium Discoideum Actin with Gelsolin
1KCQ 1.65 Å, Human Gelsolin Domain 2 with a Cd2+ bound
3CI5 1.7 Å, Complex of Phosphorylated Dictyostelium Discoideum Actin with Gelsolin
5FAE 1.7 Å, N184K pathological variant of gelsolin domain 2 (trigonal form)
5O2Z 1.7 Å, Domain swap dimer of the G167R variant of gelsolin second domain
1D4X 1.75 Å, Crystal Structure of Caenorhabditis Elegans Mg-ATP Actin Complexed with Human Gelsolin…
1NLV 1.8 Å, Crystal Structure Of Dictyostelium Discoideum Actin Complexed With Ca ATP And Human…
1NM1 1.8 Å, Crystal Structure of D. Dicsoideum Actin Complexed With Gelsolin Segment 1 and Mg ATP at…

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