Gelsolin (GSN) is a 782-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P06396.
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The mean pLDDT of this model is 89.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 76% |
| 70 to 90 | Confident: backbone generally right | 15% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed (PubMed:19666512). Plays a role in ciliogenesis (PubMed:20393563)
Binds to actin and to fibronectin. Identified in a complex composed of ACTA1, COBL, GSN and TMSB4X. Interacts with the inactive form of EIF2AK2/PKR (By similarity). Interacts with FLII (By similarity)
Cytoplasm, cytoskeleton, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5FAF | X-ray | 1.05 Å | A=178-293 |
| 6QW3 | X-ray | 1.3 Å | A=178-293 |
| 6LJE | X-ray | 1.4 Å | A/B=297-397 |
| 6LJF | X-ray | 1.5 Å | A/B=297-397 |
| 2FH1 | X-ray | 1.55 Å | A/B/C=439-782 |
| 3CIP | X-ray | 1.6 Å | G=52-176 |
| 1KCQ | X-ray | 1.65 Å | A=185-288 |
| 3CI5 | X-ray | 1.7 Å | G=52-176 |
| 5FAE | X-ray | 1.7 Å | A=178-293 |
| 5O2Z | X-ray | 1.7 Å | A/B=178-293 |
| 1D4X | X-ray | 1.75 Å | G=52-177 |
| 1NLV | X-ray | 1.8 Å | G=52-176 |
| 1NM1 | X-ray | 1.8 Å | G=52-176 |
| 4PKG | X-ray | 1.8 Å | G=52-176 |
| 1NMD | X-ray | 1.9 Å | G=52-176 |
| 1YAG | X-ray | 1.9 Å | G=52-176 |
| 6H1F | X-ray | 1.9 Å | B=178-293 |
| 1C0G | X-ray | 2.0 Å | S=53-176 |
| 1ESV | X-ray | 2.0 Å | S=52-176 |
| 1P8X | X-ray | 2.0 Å | A/B/C=439-782 |
Showing 20 of 61 experimental structures (best resolution first).
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