2H7D: Talin F3 domain

Solution structure of the talin F3 domain in complex with a chimeric beta3 integrin-PIP kinase peptide. Determined by solution NMR. Released 30 Jan 2007.

Method: Solution NMR
Organism: Gallus gallus
Chains: 2
Atoms: 1,110
Mol. weight: 15.76 kDa
Released: 30 Jan 2007

Explore 2H7D in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2H7D contains 4 α-helices and 8 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 3 helices, 7 β-strands

Element	Residues	Length	Sheet
α-helix	306-307	2
β-strand	311-318	8	1
α-helix	319	1
β-strand	325-332	8	1
β-strand	336-340	5	1
β-strand	347-352	6	1
β-strand	356-361	6	1
β-strand	365-370	6	1
β-strand	378-382	5	1
α-helix	385-402	18

Chain B: 1 helix, 1 β-strand

Element	Residues	Length	Sheet
α-helix	722-735	14
β-strand	739-741	3	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Talin-1	A	protein	101	Gallus gallus	P54939 (AlphaFold model)
Chimera of 24-mer peptide from Integrin beta-3 and 10-mer peptide from…	B	protein	34		O70161 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2H7D_1 Talin-1 (chains A)
PLGSGVSFFLVKEKMKGKNKLVPRLLGITKESVMRVDEKTKEVIQEWSLTNIKRWAASPK
SFTLDFGDYQDGYYSVQTTEGEQIAQLIAGYIDIILKKKKS

Sequence of entity 2 (B), FASTA

>2H7D_2 Chimera of 24-mer peptide from Integrin beta-3 and 10-mer peptide from Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (chains B)
KLLITIHDRKEFAKFEEERARAKWVYSPLHYSAR

Primary citation

Structural basis of integrin activation by talin. Wegener, K.L., Partridge, A.W., Han, J. et al. Cell (2007) 128:171-182. DOI 10.1016/j.cell.2006.10.048 · PubMed

Other PDB entries of the same protein (UniProt P54939 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1MIX 1.75 Å, Crystal structure of a FERM domain of Talin
1ZVZ 1.8 Å, Vinculin Head (0-258) in Complex with the Talin Rod Residue 820-844
1MIZ 1.9 Å, Crystal structure of an integrin beta3-talin chimera
1ZW2 2.1 Å, Vinculin Head (0-258) in Complex with the Talin Rod residues 2345-2369
1MK7 2.2 Å, Crystal structure of an integrin BETA3-talin chimera
1U6H 2.38 Å, Vinculin head (0-258) in complex with the talin vinculin binding site 2 (849-879)
1XWJ 2.6 Å, Vinculin head (1-258) in complex with the talin vinculin binding site 3 (1945-1969)
1RKC 2.7 Å, Human vinculin head (1-258) in complex with talin's vinculin binding site 3 (residues…
8S4Y 2.7 Å, Crystal structure of an APP-talin (F2F3) chimera
1MK9 2.8 Å, Crystal structure of an integrin BETA3-talin chimera
2H7E Solution structure of the talin F3 domain in complex with a chimeric beta3 integrin-PIP…
2HRJ NMR solution structure of the F2 subdomain of talin

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