2HYV: Annexin A2

Human Annexin A2 with heparin hexasaccharide bound. Determined by X-ray diffraction at 1.42 Å resolution. Released 5 Sept 2006.

Method: X-ray diffraction
Resolution: 1.42 Å
Organism: Homo sapiens
Chains: 1
Atoms: 3,086
Mol. weight: 36.96 kDa
Ligands: CA
Released: 5 Sept 2006

Explore 2HYV in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2HYV contains 21 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 21 helices, 0 β-strands

Element	Residues	Length
α-helix	34-46	13
α-helix	52-59	8
α-helix	64-78	15
α-helix	82-89	8
α-helix	92-102	11
α-helix	105-116	12
α-helix	124-133	10
α-helix	136-150	15
α-helix	154-160	7
α-helix	164-174	11
α-helix	178-182	5
α-helix	187-199	13
α-helix	209-218	10
α-helix	221-231	11
α-helix	239-246	8
α-helix	249-263	15
α-helix	265-277	13
α-helix	284-294	11
α-helix	299-310	12
α-helix	314-321	8
α-helix	324-334	11

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Annexin A2	A	protein	308	Homo sapiens	P07355 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2HYV_1 Annexin A2 (chains A)
NFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSAL
SGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMY
KTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVP
KWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFA
DRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKAL
LYLCGGDD

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	5

Primary citation

Crystallographic analysis of calcium-dependent heparin binding to annexin A2. Shao, C., Zhang, F., Kemp, M.M. et al. J Biol Chem (2006) 281:31689-31695. DOI 10.1074/jbc.M604502200 · PubMed

Other PDB entries of the same protein (UniProt P07355 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1W7B 1.52 Å, Annexin A2: Does it induce membrane aggregation by a new multimeric state of the protein.
7QQM 1.6 Å, The PDZ domain of LRRC7 fused with ANXA2
7PC5 1.7 Å, The third PDZ domain of PDZD7 complexed with the PDZ-binding motif of EXOC4
7P73 1.85 Å, The PDZ domain of SYNJ2BP complexed with the PDZ-binding motif of HTLV1-TAX1
2HYU 1.86 Å, Human Annexin A2 with heparin tetrasaccharide bound
7ZVN 1.87 Å, Crystal structure of human Annexin A2 in complex with full phosphorothioate 5-10…
5LPX 1.9 Å, Crystal structure of PKC phosphorylation-mimicking mutant (S26E) Annexin A2
7P74 1.9 Å, The PDZ domain of SYNJ2BP complexed with the phosphorylated PDZ-binding motif of RSK1
7PC3 1.95 Å, The second PDZ domain of DLG1 complexed with the PDZ-binding motif of HTLV1-TAX1
7P70 2.0 Å, The PDZ-domain of SNTB1 complexed with the PDZ-binding motif of HPV35-E6
7PCB 2.0 Å, The PDZ domain of SNX27 fused with ANXA2
2HYW 2.1 Å, Human Annexin A2 with Calcium bound

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