2IX7: Apo-calmodulin

Structure of apo-calmodulin bound to unconventional myosin V. Determined by X-ray diffraction at 2.5 Å resolution. Released 13 Dec 2006.

Method: X-ray diffraction
Resolution: 2.5 Å
Organism: MUS MUSCULUS
Chains: 3
Atoms: 2,935
Mol. weight: 40.42 kDa
Ligands: CYS
Released: 13 Dec 2006

Explore 2IX7 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2IX7 contains 19 α-helices and 9 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	6-19	14
β-strand	26-28	3	1
α-helix	29-31	3
α-helix	32-38	7
α-helix	45-53	9
β-strand	62-64	3	1
α-helix	65-77	13
α-helix	82-90	9
β-strand	100-101	2	2
α-helix	102-111	10
α-helix	118-127	10
β-strand	135-136	2	2
α-helix	138-144	7

Chain B: 9 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	6-18	13
β-strand	26-28	3	3
α-helix	29-31	3
α-helix	32-38	7
α-helix	45-54	10
β-strand	62-64	3	3
α-helix	65-75	11
α-helix	82-90	9
β-strand	99-101	3	4
α-helix	102-109	8
α-helix	118-126	9
β-strand	130	1	4
β-strand	135-137	3	4
α-helix	139-145	7

Chain C: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	765-818	54

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Calmodulin	A, B	protein	145	MUS MUSCULUS	P0DP26 (AlphaFold model)
Myosin-5A	C	protein	58	MUS MUSCULUS	Q99104 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>2IX7_1 CALMODULIN (chains A, B)
DQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNG
TIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEV
DEMIREADIDGDGQVNYEEFVQMMT

Sequence of entity 2 (C), FASTA

>2IX7_2 MYOSIN-5A (chains C)
ADKLRAACIRIQKTIRGWLLRKRYLCMQRAAITVQRYVRGYQARCYAKFLRRTKAATT

Ligands and cofactors

ID	Name	Formula	Copies
CYS	Cysteine	C3 H7 N O2 S	1

Water and common crystallization additives (SO4) are not listed.

Primary citation

Crystal Structure of Apo-Calmodulin Bound to the First Two Iq Motifs of Myosin V Reveals Essential Recognition Features. Houdusse, A., Gaucher, J.F., Krementsova, E. et al. Proc Natl Acad Sci U S A (2006) 103:19326. DOI 10.1073/PNAS.0609436103 · PubMed

Other PDB entries of the same protein (UniProt P0DP26 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7CQP 1.9 Å, Complex of TRPC4 and Calmodulin_Nlobe
3WFN 1.95 Å, Crystal Structure of Nav1.6 IQ motif in complex with apo-CaM
4HEX 2.0 Å, A novel conformation of calmodulin
4ZLK 2.5 Å, Crystal structure of mouse myosin-5a in complex with calcium-bound calmodulin
4E53 2.69 Å, Calmodulin and Nm peptide complex
4E50 2.7 Å, Calmodulin and Ng peptide complex
9CFV 2.7 Å, Cryo-EM structure of delta-NTR myosin-1c bound to F-actin
9CFX 2.7 Å, Cryo-EM structure of myosin-1c bound to F-actin in the Rigor state
9CFU 2.8 Å, Cryo-EM structure of myosin-1c bound to F-actin in the ADP-A state
9CFW 3.0 Å, Cryo-EM structure of myosin-1c bound to F-actin in the ADP-B state
8PB1 3.5 Å, Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling…
8W41 3.54 Å, Cryo-EM structure of Myosin VI in the autoinhibited state

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