2JGC: PDB entry 2JGC

Structure of the human eIF4E homologous protein, 4EHP without ligand bound. Determined by X-ray diffraction at 2.4 Å resolution. Released 27 Feb 2007.

Method: X-ray diffraction
Resolution: 2.4 Å
Organism: HOMO SAPIENS
Chains: 2
Atoms: 1,607
Mol. weight: 24.64 kDa
Released: 27 Feb 2007

Explore 2JGC in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2JGC contains 9 α-helices and 7 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 7 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	55-67	13	1
β-strand	82-90	9	1
α-helix	91-98	8
α-helix	102-103	2
α-helix	104-106	3
β-strand	110-117	8	1
β-strand	133-139	7	1
α-helix	144-156	13
β-strand	166-173	8	1
β-strand	178-184	7	1
α-helix	190-203	14
α-helix	206-207	2
β-strand	212-216	5	1
α-helix	229-231	3

Chain B: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	56-61	6
α-helix	62-64	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Eukaryotic translation initiation factor 4E type 2	A	protein	195	HOMO SAPIENS	O60573 (AlphaFold model)
Eukaryotic translation initiation factor 4E-binding protein 1	B	protein	17	HOMO SAPIENS	Q13541 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2JGC_1 EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 2 (chains A)
GPLHMKAVVPGPAEHPLQYNYTFWYSRRTPGRPTSSQSYEQNIKQIGTFASVEQFWRFYS
HMVRPGDLTGHSDFHLFKEGIKPMWEDDANKNGGKWIIRLRKGLASRCWENLILAMLGEQ
FMVGEEICGAVVSVRFQEDIISIWNKTASDQATTARIRDTLRRVLNLPPNTIMEYKTHTD
SIKMPGRLGPQRLLF

Sequence of entity 2 (B), FASTA

>2JGC_2 EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1 (chains B)
RIIYDRKFLMECRNSPV

Primary citation

Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms. Rosettani, P., Knapp, S., Vismara, M.G. et al. J Mol Biol (2007) 368:691-705. DOI 10.1016/j.jmb.2007.02.019 · PubMed

Other PDB entries of the same protein (UniProt O60573 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2JGB 1.7 Å, Structure of human eIF4E homologous protein 4EHP with m7GTP
5NVN 1.9 Å, Crystal structure of the human 4EHP-4E-BP1 complex
5XLN 1.9 Å, Crystal structure of the TRS_UNE-T and 4EHP complex
5NVM 2.0 Å, Crystal structure of the human 4EHP-GIGYF2 complex lacking the auxiliary sequences
5NVL 2.3 Å, Crystal structure of the human 4EHP-GIGYF2 complex
5NVK 2.9 Å, Crystal structure of the human 4EHP-GIGYF1 complex

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