2MES: Calmodulin

Backbone 1H, 13C, 15N resonance assignments of calcium-bound calmodulin in complex with PSD95 N-terminal peptide. Determined by solution NMR. Released 24 Dec 2014.

Method: Solution NMR
Organisms: Xenopus laevis, Homo sapiens
Chains: 2
Atoms: 1,297
Mol. weight: 24.88 kDa
Ligands: CA
Released: 24 Dec 2014

Explore 2MES in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2MES contains 9 α-helices and 4 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	6-19	14
β-strand	27	1	1
α-helix	29-37	9
α-helix	45-55	11
β-strand	63	1	1
α-helix	65-76	12
α-helix	84-92	9
β-strand	99-101	3	2
α-helix	104-112	9
α-helix	118-125	8
β-strand	135-137	3	2
α-helix	138-145	8

Chain B: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	2-15	14

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Calmodulin	A	protein	148	Xenopus laevis	P0DP33 (AlphaFold model)
Disks large homolog 4	B	protein	71	Homo sapiens	P78352 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2MES_1 Calmodulin (chains A)
ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGN
GTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEE
VDEMIREADIDGDGQVNYEEFVQMMTAK

Sequence of entity 2 (B), FASTA

>2MES_2 Disks large homolog 4 (chains B)
MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGE
MEYEEITLERG

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	4

Primary citation

Capping of the N-terminus of PSD-95 by calmodulin triggers its postsynaptic release. Zhang, Y., Matt, L., Patriarchi, T. et al. EMBO J (2014) 33:1341-1353. DOI 10.1002/embj.201488126 · PubMed

Other PDB entries of the same protein (UniProt P0DP33 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1IQ5 1.8 Å, Calmodulin/nematode CA2+/Calmodulin dependent kinase kinase fragment
2COL 2.2 Å, Crystal structure analysis of CyaA/C-Cam with Pyrophosphate
4R8G 3.5 Å, Crystal Structure of Myosin-1c tail in complex with Calmodulin
1Y0V 3.6 Å, Crystal structure of anthrax edema factor (EF) in complex with calmodulin and…
1CFC Calcium-free calmodulin
1CFD Calcium-free calmodulin
1CFF NMR solution structure of a complex of calmodulin with a binding peptide of the CA2+-pump
1CKK Calmodulin/rat CA2+/CALMODULIN dependent protein kinase fragment
1DMO Calmodulin, NMR, 30 structures
1F70 Refined solution structure of calmodulin N-terminal domain
1F71 Refined solution structure of calmodulin C-terminal domain
1MUX Solution NMR structure of calmodulin/w-7 complex: the basis of diversity in molecular…

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