2N97: DD homodimer

DD homodimer. Determined by solution NMR. Released 23 Dec 2015.

Method: Solution NMR
Organism: Homo sapiens
Chains: 2
Atoms: 1,428
Mol. weight: 21.06 kDa
Released: 23 Dec 2015

Explore 2N97 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2N97 contains 14 α-helices and 4 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 7 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	335	1	1
α-helix	336-338	3
α-helix	341-353	13
α-helix	358-365	8
α-helix	370-376	7
α-helix	382-391	10
β-strand	397	1	1
α-helix	398-407	10
α-helix	411-419	9

Chain B: 7 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	335	1	2
α-helix	336-338	3
α-helix	341-353	13
α-helix	358-366	9
α-helix	370-376	7
α-helix	382-390	9
β-strand	397	1	2
α-helix	398-407	10
α-helix	411-419	9

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Tumor necrosis factor receptor superfamily member 16	A, B	protein	98	Homo sapiens	P08138 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>2N97_1 Tumor necrosis factor receptor superfamily member 16 (chains A, B)
KGDGGLYSSLPPAKREEVEKLLNGSAGDTWRHLAGELGYQPEHIDSFTHEACPVRALLAS
WATQDSATLDALLAALRRIQRADLVESLCSESTATSPV

Primary citation

Structural basis of death domain signaling in the p75 neurotrophin receptor. Lin, Z., Tann, J.Y., Goh, E.T. et al. Elife (2015) 4:11692-11692. DOI 10.7554/eLife.11692 · PubMed

Other PDB entries of the same protein (UniProt P08138 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3EWV 2.6 Å, Crystal Structure of calmodulin complexed with a peptide
2N80 p75NTR DD:RhoGDI
2N83 p75NTR DD:RIP2 card
5ZGG NMR structure of p75NTR transmembrane domain in complex with NSC49652
7CSQ Solution structure of the complex between p75NTR-DD and TRADD-DD
8X8T NMR structure of p75NTR juxtamembrane domain in complex with RhoGDI N-terminal domain…

Browse structure collections

About this viewer

MolViewer shows 2N97 directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.