2O72: Crystal Structure Analysis of human E-cadherin

Crystal Structure Analysis of human E-cadherin (1-213). Determined by X-ray diffraction at 2.0 Å resolution. Released 9 Oct 2007.

Method: X-ray diffraction
Resolution: 2.0 Å
Organism: Homo sapiens
Chains: 1
Atoms: 1,877
Mol. weight: 23.34 kDa
Ligands: CA
Released: 9 Oct 2007

Explore 2O72 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2O72 contains 4 α-helices and 19 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 4 helices, 19 β-strands

Element	Residues	Length	Sheet
α-helix	4-6	3
β-strand	7-10	4	1
β-strand	19-23	5	2
α-helix	27-30	4
β-strand	34-39	6	1
β-strand	41	1	3
β-strand	45	1	3
β-strand	51-53	3	2
β-strand	59-62	4	2
β-strand	73-82	10	1
β-strand	87	1	1
β-strand	92-99	8	1
α-helix	100	1
β-strand	107-108	2	4
β-strand	112-118	7	5
α-helix	121-122	2
β-strand	126-129	4	6
β-strand	132-133	2	4
β-strand	147-154	8	5
β-strand	163-165	3	6
β-strand	171-174	4	6
β-strand	186-194	9	5
β-strand	202-212	11	5

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Epithelial-cadherin	A	protein	213	Homo sapiens	P12830 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2O72_1 Epithelial-cadherin (chains A)
DWVIPPISSPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGVFIIERETGWL
KVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEG
ALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLD
RESFPTYTLVVQAADLQGEGLSTTATAVITVTD

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	5

Primary citation

The Crystal Structure of Human E-cadherin Domains 1 and 2, and Comparison with other Cadherins in the Context of Adhesion Mechanism. Parisini, E., Higgins, J.M.G., Liu, J.-H. et al. J Mol Biol (2007) 373:401-411. DOI 10.1016/j.jmb.2007.08.011 · PubMed

Other PDB entries of the same protein (UniProt P12830 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2OMZ 1.6 Å, Crystal structure of InlA Y369A/hEC1 complex
2OMX 1.7 Å, Crystal structure of InlA S192N G194S+S/hEC1 complex
2OMY 1.7 Å, Crystal structure of InlA S192N/hEC1 complex
1O6S 1.8 Å, Internalin (Listeria monocytogenes) / E-Cadherin (human) Recognition Complex
2OMU 1.8 Å, Crystal structure of InlA G194S+S Y369S/hEC1 complex
3FF7 1.8 Å, Structure of NK cell receptor KLRG1 bound to E-cadherin
2OMV 1.9 Å, Crystal structure of InlA S192N Y369S/hEC1 complex
8H62 1.91 Å, Crystal structure of Internalin A from Listeria monocytogenes with human E-cadherin EC12
4ZT1 1.92 Å, Crystal structure of human E-Cadherin (residues 3-213) in x-dimer conformation
2OMT 2.0 Å, Crystal structure of InlA G194S+S/hEC1 complex
3FF8 2.0 Å, Structure of NK cell receptor KLRG1 bound to E-cadherin
4ZTE 2.13 Å, Crystal structure of human E-Cadherin (residues 3-213) in complex with a peptidomimetic…

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