2O9S: The second SH3 domain from ponsin

The second SH3 domain from ponsin. Determined by X-ray diffraction at 0.83 Å resolution. Released 30 Oct 2007.

Method: X-ray diffraction
Resolution: 0.83 Å
Organism: Homo sapiens
Chains: 1
Atoms: 786
Mol. weight: 7.87 kDa
Ligands: SCN
Released: 30 Oct 2007

Explore 2O9S in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2O9S contains 2 α-helices and 8 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	824-828	5	1
β-strand	832	1	2
β-strand	839	1	1
α-helix	840-841	2
β-strand	842	1	2
β-strand	847-853	7	1
β-strand	858-862	5	1
β-strand	869-873	5	1
α-helix	874-876	3
β-strand	877-881	5	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Ponsin	A	protein	67	Homo sapiens	Q9BX66 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2O9S_1 Ponsin (chains A)
GIDPFTGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYV
DVIKRPL

Ligands and cofactors

ID	Name	Formula	Copies
SCN	Thiocyanate ion	C N S	2

Water and common crystallization additives (CL, NA) are not listed.

Primary citation

Paxillin and ponsin interact in nascent costameres of muscle cells. Gehmlich, K., Pinotsis, N., Hayess, K. et al. J Mol Biol (2007) 369:665-682. DOI 10.1016/j.jmb.2007.03.050 · PubMed

Other PDB entries of the same protein (UniProt Q9BX66 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4LN2 1.0 Å, The second SH3 domain from CAP/Ponsin in complex with proline rich peptide from Vinculin
4LNP 1.41 Å, The first SH3 domain from CAP/Ponsin in complex with proline rich peptide from Vinculin
2O31 1.5 Å, Crystal structure of the second SH3 domain from ponsin
2O9V 1.63 Å, The second SH3 domain from Ponsin in complex with the paxillin proline rich region
2DL3 Solution structure of the first SH3 domain of human sorbin and Sh3 domain-containing…
2ECZ Solution structure of the SH3 domain of Sorbin and SH3 domain-containing protein 1
2LJ0 The third SH3 domain of R85FL
2LJ1 The third SH3 domain of R85FL with ataxin-7 PRR
2MOX solution structure of tandem SH3 domain of Sorbin and SH3 domain-containing protein 1
2O2W Extending powder diffraction to proteins: structure solution of the second SH3 domain…

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