2Q5D: Human Importin Beta

Crystal Structure of Human Importin Beta bound to the Snurportin1 IBB-domain second crystal form. Determined by X-ray diffraction at 3.2 Å resolution. Released 22 Jan 2008.

Method

X-ray diffraction

Resolution

3.2 Å

Organism

Homo sapiens

Chains

4

Atoms

13,750

Mol. weight

204.57 kDa

Released

22 Jan 2008

Explore 2Q5D in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2Q5D contains 116 α-helices and 0 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 62 helices, 0 β-strands

Molecules and chains

>2Q5D_1 Importin beta-1 subunit (chains A, B)
MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQ
IKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAE
IPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQG
MRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQN
LVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEA
AEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCE
DDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDP
SVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEA
AYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSA
KDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDA
LQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKN
YAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDI
ALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQ
ENVHPDVMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEAR
PMIHELLTEGRRSKTNKAKTLATWATKELRKLKNQA

>2Q5D_2 Snurportin-1 (chains C, D)
HPRLSQYKSKYSSLEQSERRRRLLELQKSKRLDYVNHARR

Primary citation

Molecular Basis for the Recognition of Snurportin 1 by Importin {beta}. Mitrousis, G., Olia, A.S., Walker-Kopp, N. et al. J Biol Chem (2008) 283:7877-7884. DOI 10.1074/jbc.M709093200 · PubMed

Related structures

Other PDB entries of the same protein (UniProt Q14974 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 1IBR 2.3 Å, Complex of ran with importin beta
• 1QGR 2.3 Å, Structure of importin beta bound to the ibb domain of importin alpha (II crystal form,…
• 2P8Q 2.35 Å, Crystal Structure of human Importin beta bound to the Snurportin1 IBB-domain
• 1QGK 2.5 Å, Structure of importin beta bound to the ibb domain of importin alpha
• 3W5K 2.6 Å, Crystal structure of Snail1 and importin beta complex
• 9N85 2.6 Å, Cryo-EM structure of human importin beta:Ran-GTP:RanBP1 trimeric complex
• 1F59 2.8 Å, Importin-beta-fxfg nucleoporin complex
• 1O6O 2.8 Å, Importin Beta aa1-442 bound to five FxFG repeats from yeast Nsp1p. Second crystal form
• 1O6P 2.8 Å, Importin Beta bound to a GLFG Nucleoporin peptide
• 2QNA 2.84 Å, Crystal structure of human Importin-beta (127-876) in complex with the IBB-domain of…
• 1M5N 2.9 Å, Crystal structure of HEAT repeats (1-11) of importin b bound to the non-classical…
• 3LWW 3.15 Å, Structure of an open and closed conformation of Human Importin Beta bound to the…

Browse structure collections

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