Solution structure of the complex between the DDEF1 SH3 domain and the APC SAMP1 motif. Determined by solution NMR. Released 7 Jul 2010.
Explore 2RQU in 3D Show helices and sheets RCSB PDB PDBe
2RQU contains 1 α-helix and 8 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 1070-1074 | 5 | 1 |
| β-strand | 1078 | 1 | 2 |
| β-strand | 1085 | 1 | 1 |
| β-strand | 1088 | 1 | 2 |
| β-strand | 1093-1099 | 7 | 1 |
| β-strand | 1104-1109 | 6 | 1 |
| β-strand | 1116-1120 | 5 | 1 |
| α-helix | 1121-1123 | 3 | |
| β-strand | 1124-1126 | 3 | 1 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| DDEF1_SH3 | A | protein | 61 | Homo sapiens | Q9ULH1 (AlphaFold model) |
| 19-mer from Adenomatous polyposis coli protein | B | protein | 19 | Homo sapiens | P25054 |
>2RQU_1 DDEF1_SH3 (chains A) VRRVKTIYDCQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILS D
>2RQU_2 19-mer from Adenomatous polyposis coli protein (chains B) CIISAMPTKSSRKAKKPAQ
Structural basis of the recognition of the SAMP motif of adenomatous polyposis coli by the Src-homology 3 domain. Kaieda, S., Matsui, C., Mimori-Kiyosue, Y. et al. Biochemistry (2010) 49:5143-5153. DOI 10.1021/bi100563z · PubMed
Other PDB entries of the same protein (UniProt Q9ULH1 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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