Structural comparison of two serine proteinase-protein inhibitor complexes. Eglin-C-subtilisin carlsberg and ci-2-subtilisin novo. Determined by X-ray diffraction at 2.1 Å resolution. Released 7 Sept 1988.
Explore 2SNI in 3D Show helices and sheets RCSB PDB PDBe
2SNI contains 15 α-helices and 30 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 6-10 | 5 | |
| α-helix | 13-18 | 6 | |
| β-strand | 27-32 | 6 | 1 |
| β-strand | 44-49 | 6 | 1 |
| β-strand | 51 | 1 | 2 |
| β-strand | 54 | 1 | 2 |
| α-helix | 64-73 | 10 | |
| β-strand | 89-94 | 6 | 1 |
| β-strand | 101-103 | 3 | 3 |
| α-helix | 104-116 | 13 | |
| β-strand | 121-124 | 4 | 1 |
| β-strand | 126-127 | 2 | 3 |
| β-strand | 128 | 1 | 4 |
| α-helix | 133-144 | 12 | |
| β-strand | 148-152 | 5 | 1 |
| β-strand | 159 | 1 | 5 |
| β-strand | 162 | 1 | 5 |
| β-strand | 167 | 1 | 4 |
| β-strand | 175-180 | 6 | 1 |
| α-helix | 185 | 1 | |
| β-strand | 186 | 1 | 1 |
| α-helix | 187 | 1 | |
| β-strand | 198-201 | 4 | 1 |
| β-strand | 205-209 | 5 | 6 |
| β-strand | 213-217 | 5 | 6 |
| β-strand | 219 | 1 | 7 |
| α-helix | 220-237 | 18 | |
| α-helix | 243-252 | 10 | |
| α-helix | 254 | 1 | |
| β-strand | 255 | 1 | 1 |
| α-helix | 256 | 1 | |
| α-helix | 260-263 | 4 | |
| β-strand | 267 | 1 | 1 |
| α-helix | 270-274 | 5 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 23 | 1 | 8 |
| α-helix | 25-27 | 3 | |
| β-strand | 31 | 1 | 9 |
| α-helix | 32-42 | 11 | |
| β-strand | 47-52 | 6 | 8 |
| β-strand | 55-58 | 4 | 3 |
| β-strand | 60 | 1 | 7 |
| β-strand | 65-70 | 6 | 8 |
| β-strand | 75 | 1 | 9 |
| β-strand | 76 | 1 | 8 |
| β-strand | 81-82 | 2 | 8 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Subtilisin novo | E | protein | 275 | Bacillus amyloliquefaciens | P00782 (AlphaFold model) |
| Chymotrypsin inhibitor 2 | I | protein | 83 | Hordeum sp. | P01053 (AlphaFold model) |
>2SNI_1 SUBTILISIN NOVO (chains E) AQSVPYGVSQIKAPALHSQGYTGSNVKVAVIDSGIDSSHPDLKVAGGASMVPSETNPFQD NNSHGTHVAGTVAALNNSIGVLGVAPSASLYAVKVLGADGSGQYSWIINGIEWAIANNMD VINMSLGGPSGSAALKAAVDKAVASGVVVVAAAGNEGTSGSSSTVGYPGKYPSVIAVGAV DSSNQRASFSSVGPELDVMAPGVSIQSTLPGNKYGAYNGTSMASPHVAGAAALILSKHPN WTNTQVRSSLQNTTTKLGDSFYYGKGLINVQAAAQ
>2SNI_2 CHYMOTRYPSIN INHIBITOR 2 (chains I) SSVEKKPEGVNTGAGDRHNLKTEWPELVGKSVEEAKKVILQDKPEAQIIVLPVGTIVTME YRIDRVRLFVDKLDNIAEVPRVG
| ID | Name | Formula | Copies |
|---|---|---|---|
| CA | Calcium ion | Ca | 2 |
Structural comparison of two serine proteinase-protein inhibitor complexes: eglin-c-subtilisin Carlsberg and CI-2-subtilisin Novo. McPhalen, C.A., James, M.N. Biochemistry (1988) 27:6582-6598. DOI 10.1021/bi00417a058 · PubMed
Other PDB entries of the same protein (UniProt P00782 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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