2VWF: Grb2 SH3C

Grb2 SH3C (2). Determined by X-ray diffraction at 1.58 Å resolution. Released 19 May 2009.

Method: X-ray diffraction
Resolution: 1.58 Å
Organism: HOMO SAPIENS
Chains: 2
Atoms: 615
Mol. weight: 8.39 kDa
Released: 19 May 2009

Explore 2VWF in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2VWF contains 4 α-helices and 8 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	2-5	4	1
β-strand	9	1	2
β-strand	16	1	1
α-helix	17-18	2
β-strand	19	1	2
β-strand	24-29	6	1
β-strand	35-40	6	1
β-strand	43-48	6	1
α-helix	49-51	3
β-strand	52-54	3	1

Chain B: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	3-6	4
α-helix	8-10	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Growth factor receptor-bound protein 2	A	protein	58	HOMO SAPIENS	P62993 (AlphaFold model)
GRB2-associated-binding protein 2	B	protein	15	HOMO SAPIENS	Q9UQC2 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2VWF_1 GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 (chains A)
GPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTAVN

Sequence of entity 2 (B), FASTA

>2VWF_2 GRB2-ASSOCIATED-BINDING PROTEIN 2 (chains B)
IQPPPVNRNLKPDRK

Primary citation

Distinct Binding Modes of Two Epitopes in Gab2 that Interact with the Sh3C Domain of Grb2. Harkiolaki, M., Tsirka, T., Lewitzky, M. et al. Structure (2009) 17:809. DOI 10.1016/J.STR.2009.03.017 · PubMed

Other PDB entries of the same protein (UniProt P62993 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6ICG 1.15 Å, Grb2 SH2 domain in phosphopeptide free form
3WA4 1.35 Å, Grb2 SH2 domain/CD28-derived peptide complex
1JYR 1.55 Å, Xray Structure of Grb2 SH2 Domain Complexed with a Phosphorylated Peptide
2VVK 1.6 Å, Grb2 SH3C (1)
3OV1 1.6 Å, Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide
4P9V 1.64 Å, Grb2 SH2 complexed with a pTyr-Ac6cN-Asn tripeptide
1GCQ 1.68 Å, Crystal structure of vav and GRB2 SH3 domains
2W0Z 1.7 Å, Grb2 SH3C (3)
3C7I 1.7 Å, X-RAY crystal structure of the complex between the grb2-sh2 domain and a flexible…
3IN8 1.7 Å, Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pTyr-Ile-Asn-NH2…
3S8L 1.71 Å, Protein-Ligand Interactions: Thermodynamic Effects Associated with Increasing…
3S8N 1.71 Å, Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide

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