2W99: CDK4

Crystal Structure of CDK4 in complex with a D-type cyclin. Determined by X-ray diffraction at 2.8 Å resolution. Released 10 Mar 2009.

Method: X-ray diffraction
Resolution: 2.8 Å
Organism: HOMO SAPIENS
Chains: 2
Atoms: 4,385
Mol. weight: 65.53 kDa
Released: 10 Mar 2009

Explore 2W99 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2W99 contains 26 α-helices and 15 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 15 helices, 0 β-strands

Element	Residues	Length
α-helix	23-37	15
α-helix	44-47	4
α-helix	54-70	17
α-helix	77-89	13
α-helix	96-98	3
α-helix	99-114	16
α-helix	118-120	3
α-helix	121-126	6
α-helix	134-147	14
α-helix	157-167	11
α-helix	172-190	19
α-helix	194-197	4
α-helix	200-218	19
α-helix	229-237	9
α-helix	241-261	21

Chain B: 11 helices, 15 β-strands

Element	Residues	Length	Sheet
β-strand	7-8	2	1
β-strand	14-15	2	2
β-strand	18-19	2	2
β-strand	23-25	3	1
β-strand	30-32	3	1
β-strand	38-39	2	3
β-strand	42	1	4
β-strand	48	1	4
α-helix	51-61	11
β-strand	71	1	5
β-strand	74-83	10	3
β-strand	86-93	8	3
β-strand	94	1	1
β-strand	98-99	2	6
α-helix	100-105	6
α-helix	118-133	16
β-strand	147-148	2	6
β-strand	156	1	5
α-helix	166-170	5
α-helix	194-206	13
α-helix	219-230	12
α-helix	232-234	3
α-helix	254-256	3
α-helix	257-260	4
α-helix	266-275	10
α-helix	289-291	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
G1/S-specific cyclin-D1	A	protein	271	HOMO SAPIENS	P24385 (AlphaFold model)
Cell division protein kinase 4	B	protein	306	HOMO SAPIENS	P11802 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2W99_1 G1/S-SPECIFIC CYCLIN-D1 (chains A)
MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIV
ATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLT
AEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRK
HAQTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCD
PDCLRACQEQIEALLESSLRQAQQNMDPKAA

Sequence of entity 2 (B), FASTA

>2W99_2 CELL DIVISION PROTEIN KINASE 4 (chains B)
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRL
EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ
FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALAPVVVTLWYRAP
EVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS
LPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
HHHHHH

Primary citation

Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin. Day, P.J., Cleasby, A., Tickle, I.J. et al. Proc Natl Acad Sci U S A (2009) 106:4166. DOI 10.1073/PNAS.0809645106 · PubMed

Other PDB entries of the same protein (UniProt P24385 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9CSK 2.25 Å, Crystal structure of CDK4 cyclin D1 in complex with atirmociclib
2W96 2.3 Å, Crystal Structure of CDK4 in complex with a D-type cyclin
6P8E 2.3 Å, Crystal structure of CDK4 in complex with CyclinD1 and P27
2W9Z 2.45 Å, Crystal Structure of CDK4 in complex with a D-type cyclin
5VZU 2.7 Å, Crystal structure of the Skp1-FBXO31-cyclin D1 complex
6P8G 2.8 Å, Crystal structure of CDK4 in complex with CyclinD1 and P27
2W9F 2.85 Å, Crystal Structure of CDK4 in complex with a D-type cyclin
6P8F 2.89 Å, Crystal structure of CDK4 in complex with CyclinD1 and P27
6P8H 3.19 Å, Crystal structure of CDK4 in complex with CyclinD1 and P21
9IVD 3.55 Å, Cryo-EM structure of CyclinD1 bound AMBRA1-DDB1

Browse structure collections

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