2WVR: Human Cdt1:Geminin complex

Name: PDB 2WVR: Human Cdt1:Geminin complex
Published: 2009-10-27
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: replication

Human Cdt1:Geminin complex. Determined by X-ray diffraction at 3.3 Å resolution. Released 27 Oct 2009.

Method: X-ray diffraction
Resolution: 3.3 Å
Organism: HOMO SAPIENS
Chains: 3
Atoms: 2,611
Mol. weight: 107.73 kDa
Released: 27 Oct 2009

Explore 2WVR in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2WVR contains 14 α-helices and 3 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	98-159	62

Chain B: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	96-145	50
α-helix	149-158	10

Chain C: 11 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	169-172	4
α-helix	174-177	4
α-helix	185-187	3
α-helix	188-209	22
β-strand	215	1	1
α-helix	216-227	12
α-helix	233-242	10
α-helix	244-246	3
β-strand	247-251	5	1
β-strand	269-273	5	1
α-helix	288-314	27
α-helix	325-327	3
α-helix	341-342	2
α-helix	344-351	8

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Geminin	A, B	protein	209	HOMO SAPIENS	O75496 (AlphaFold model)
DNA replication factor CDT1	C	protein	546	HOMO SAPIENS	Q9H211 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>2WVR_1 GEMININ (chains A, B)
MNPSMKQKQEEIKENIKNSSVPRRTLKMIQPSASGSLVGRENELSAGLSKRKHRNDHLTS
TTSSPGVIVPESSENKNLGGVTQESFDLMIKENPSSQYWKEVAEKRRKALYEALKENEKL
HKEIEQKDNEIARLKKENKELAEVAEHVQYMAELIERLNGEPLDNFESLDNQEFDSEEET
VEDSLVEDSEIGTCAEGTVSSSTDAKPCI

Sequence of entity 2 (C), FASTA

>2WVR_2 DNA REPLICATION FACTOR CDT1 (chains C)
MEQRRVTDFFARRRPGPPRIAPPKLACRTPSPARPALRAPASATSGSRKRARPPAAPGRD
QARPPARRRLRLSVDEVSSPSTPEAPDIPACPSPGQKIKKSTPAAGQPPHLTSAQDQDTI
SELASCLQRARELGARVRALKASAQDAGESCTPEAEGRPEEPCGEKAPAYQRFHALAQPG
LPGLVLPYKYQVLAEMFRSMDTIVGMLHNRSETPTFAKVQRGVQDMMRRRFEERNVGQIK
TVYPASYRFRQERSVPTFKDGTRRSDYQLTIEPLLEQEADGAAPQLTASRLLQRRQIFSQ
KLVEHVKEHHKAFLASLSPAMVVPEDQLTRWHPRFNVDEVPDIEPAALPQPPATEKLTTA
QEVLARARNLISPRMEKALSQLALRSAAPSSPGSPRPALPATPPATPPAASPSALKGVSQ
DLLERIRAKEAQKQLAQMTRCPEQEQRLQRLERLPELARVLRSVFVSERKPALSMEVACA
RMVGSCCTIMSPGEMEKHLLLLSELLPDWLSLHRIRTDTYVKLDKAADLAHITARLAHQT
RAEEGL

Primary citation

Quaternary Structure of the Human Cdt1-Geminin Complex Regulates DNA Replication Licensing. De Marco, V., Gillespie, P.J., Li, A. et al. Proc Natl Acad Sci U S A (2009) 106:19807. DOI 10.1073/PNAS.0905281106 · PubMed

Other PDB entries of the same protein (UniProt O75496 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1T6F 1.47 Å, Crystal Structure of the Coiled-coil Dimerization Motif of Geminin
1UII 2.0 Å, Crystal structure of Geminin coiled-coil domain
4BRY 2.89 Å, The Idas:Geminin heterodimeric parallel coiled-coil
7KLZ 3.4 Å, Structure of SPOP MATH domain in complex with a Geminin peptide
2LP0 The solution structure of homeodomain-protein complex

Browse structure collections

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