2XV5: Human lamin A coil 2B fragment

Human lamin A coil 2B fragment. Determined by X-ray diffraction at 2.4 Å resolution. Released 9 Mar 2011.

Method: X-ray diffraction
Resolution: 2.4 Å
Organism: HOMO SAPIENS
Chains: 2
Atoms: 970
Mol. weight: 17.9 kDa
Released: 9 Mar 2011

Explore 2XV5 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2XV5 contains 2 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and B: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	327-379	53

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Lamin-a/c	A, B	protein	74	HOMO SAPIENS	P02545 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>2XV5_1 LAMIN-A/C (chains A, B)
GGSARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEE
ERLRLSPSPTSQRS

Primary citation

Simultaneous Formation of Right- and Left-Handed Anti-Parallel Coiled-Coil Interfaces by a Coil2 Fragment of Human Lamin A. Kapinos, L.E., Burkhard, P., Herrmann, H. et al. J Mol Biol (2011) 408:135. DOI 10.1016/J.JMB.2011.02.037 · PubMed

Other PDB entries of the same protein (UniProt P02545 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7WZZ 1.3 Å, Crystal structure of peptide KAGQVVTIW in complex with HLA-B5801
7X1B 1.4 Å, Crystal structure of peptide KAGQVVTI in complex with HLA-B5801
1IFR 1.4 Å, Structure of Lamin A/C Globular Domain
3GEF 1.5 Å, Crystal structure of the R482W mutant of lamin A/C
8I33 1.62 Å, Coil 1a of lamin A (residue 25-65)
7Z21 1.63 Å, BAF A12T bound to the lamin A/C Ig-fold domain
7CRG 1.8 Å, Beta-strand-mediated dimeric formation of the extended Ig-like domains of human lamin A/C
7X5D 1.82 Å, Crystal Structure of the K316C mutant of Human Lamin A/C Coil 2 (residues 244-340)
6YF5 1.83 Å, Lamin A 17-70 coil1A dimer stabilized by C-terminal capping
6GHD 2.1 Å, Structural analysis of the ternary complex between lamin A/C, BAF and emerin identifies…
7YVD 2.1 Å, The crystal structure of the progerin C-terminal peptide and the Ig-like domain of lamin…
1X8Y 2.2 Å, Human lamin coil 2B

Browse structure collections

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