Upf1 helicase. Determined by X-ray diffraction at 2.72 Å resolution. Released 30 Mar 2011.
Explore 2XZP in 3D Show helices and sheets RCSB PDB PDBe
2XZP contains 37 α-helices and 28 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 299-322 | 24 | |
| β-strand | 326-329 | 4 | 1 |
| β-strand | 332-335 | 4 | 1 |
| β-strand | 341-346 | 6 | 1 |
| α-helix | 352-355 | 4 | |
| α-helix | 356-357 | 2 | |
| β-strand | 361-366 | 6 | 1 |
| β-strand | 374-382 | 9 | 1 |
| α-helix | 389 | 1 | |
| β-strand | 390-395 | 6 | 1 |
| β-strand | 409-413 | 5 | 1 |
| α-helix | 414-415 | 2 | |
| α-helix | 418-432 | 15 | |
| β-strand | 437 | 1 | 2 |
| α-helix | 439-445 | 7 | |
| α-helix | 465 | 1 | |
| α-helix | 469-471 | 3 | |
| α-helix | 473-483 | 11 | |
| β-strand | 487-491 | 5 | 3 |
| α-helix | 498-511 | 14 | |
| α-helix | 516 | 1 | |
| β-strand | 517-521 | 5 | 3 |
| α-helix | 524-536 | 13 | |
| β-strand | 541-543 | 3 | 3 |
| α-helix | 547-549 | 3 | |
| α-helix | 557-559 | 3 | |
| β-strand | 560 | 1 | 3 |
| α-helix | 561-564 | 4 | |
| α-helix | 572-583 | 12 | |
| α-helix | 589-609 | 21 | |
| β-strand | 612-616 | 5 | 3 |
| α-helix | 618-621 | 4 | |
| β-strand | 632-635 | 4 | 3 |
| α-helix | 638-640 | 3 | |
| α-helix | 643-650 | 8 | |
| β-strand | 654 | 1 | 2 |
| β-strand | 656-661 | 6 | 3 |
| α-helix | 673-675 | 3 | |
| α-helix | 676-680 | 5 | |
| α-helix | 684-690 | 7 | |
| α-helix | 694-695 | 2 | |
| β-strand | 696-697 | 2 | 3 |
| α-helix | 698 | 1 | |
| β-strand | 700-701 | 2 | 4 |
| α-helix | 706-716 | 11 | |
| β-strand | 722-723 | 2 | 4 |
| β-strand | 746-750 | 5 | 5 |
| β-strand | 756-758 | 3 | 6 |
| β-strand | 763-765 | 3 | 6 |
| α-helix | 767-782 | 16 | |
| α-helix | 787-789 | 3 | |
| β-strand | 790-793 | 4 | 5 |
| α-helix | 797-810 | 14 | |
| α-helix | 815-819 | 5 | |
| β-strand | 822-824 | 3 | 5 |
| α-helix | 826-829 | 4 | |
| β-strand | 834-840 | 7 | 5 |
| α-helix | 851-853 | 3 | |
| α-helix | 856-863 | 8 | |
| β-strand | 866-874 | 9 | 5 |
| α-helix | 876-879 | 4 | |
| α-helix | 883-894 | 12 | |
| β-strand | 898-900 | 3 | 5 |
| α-helix | 903-905 | 3 | |
| β-strand | 907-908 | 2 | 5 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Regulator of nonsense transcripts 1 | A | protein | 623 | HOMO SAPIENS | Q92900 (AlphaFold model) |
>2XZP_1 REGULATOR OF NONSENSE TRANSCRIPTS 1 (chains A) GHMRYEDAYQYQNIFGPLVKLEADYDKKLKESQTQDNITVRWDLGLNKKRIAYFTLPKTD SDMRLMQGDEICLRYKGDLAPLWKGIGHVIKVPDNYGDEIAIELRSSVGAPVEVTHNFQV DFVWKSTSFDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQLPKRFTAQGLPDL NHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNGPVLVCAPSNIAVDQLT EKIHQTGLKVVRLCAKSREAIDSPVSFLALHNQIRNMDSMPELQKLQQLKDETGELSSAD EKRYRALKRTAERELLMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVPVV LGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIRPIRLQVQYRMHPALSAF PSNIFYEGSLQNGVTAADRVKKGFDFQWPQPDKPMFFYVTQGQEEIASSGTSYLNRTEAA NVEKITTKLLKAGAKPDQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQEVEIASVDAFQG REKDFIILSCVRANEHQGIGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLLNY YKEQKVLVEGPLNNLRESLMQFS
| ID | Name | Formula | Copies |
|---|---|---|---|
| MLI | Malonate ion | C3 H2 O4 | 2 |
Water and common crystallization additives (GOL) are not listed.
Molecular Mechanisms for the RNA-Dependent ATPase Activity of Upf1 and its Regulation by Upf2. Chakrabarti, S., Jayachandran, U., Bonneau, F. et al. Mol Cell (2011) 41:693. DOI 10.1016/J.MOLCEL.2011.02.010 · PubMed
Other PDB entries of the same protein (UniProt Q92900 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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