2YQ7: Bcl-xL

Structure of Bcl-xL bound to BimLOCK. Determined by X-ray diffraction at 1.9 Å resolution. Released 28 Nov 2012.

Method: X-ray diffraction
Resolution: 1.9 Å
Organism: HOMO SAPIENS
Chains: 2
Atoms: 1,455
Mol. weight: 20.22 kDa
Released: 28 Nov 2012

Explore 2YQ7 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2YQ7 contains 11 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 10 helices, 0 β-strands

Element	Residues	Length
α-helix	-3-18	22
α-helix	26-100	19
α-helix	102-110	9
α-helix	116-118	3
α-helix	119-130	12
α-helix	137-156	20
α-helix	161-173	13
α-helix	174-178	5
α-helix	179-184	6
α-helix	187-195	9

Chain B: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	148-163	16

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Bcl-2-like protein 1	A	protein	158	HOMO SAPIENS	Q07817 (AlphaFold model)
Bcl-2-like protein 11	B	protein	20	HOMO SAPIENS	O43521 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2YQ7_1 BCL-2-LIKE PROTEIN 1 (chains A)
GPLGSMSQSNRELVVDFLSYKLSQKGYSWSQMAAVKQALREAGDEFELRYRRAFSDLTSQ
LHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMA
TYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQER

Sequence of entity 2 (B), FASTA

>2YQ7_2 BCL-2-LIKE PROTEIN 11 (chains B)
XWIAQELREIGDKFNAYYAX

Primary citation

Stabilizing the Pro-Apoptotic Bimbh3 Helix (Bimsahb) Does not Necessarily Enhance Affinity or Biological Activity. Okamoto, T., Zobel, K., Fedorova, A. et al. ACS Chem Biol (2013) 8:297. DOI 10.1021/CB3005403 · PubMed

Other PDB entries of the same protein (UniProt Q07817 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7JGW 1.3 Å, Crystal structure of BCL-XL in complex with COMPOUND 1620116, CRYSTAL FORM 1
3SP7 1.4 Å, Crystal Structure of Bcl-xL bound to BM903
7YAA 1.4 Å, Crystal structure analysis of cp3 bound BCLxl
7LH7 1.41 Å, Crystal structure of BCL-XL in complex with a benzothiazole-based inhibitor
9IGG 1.5 Å, Structure of human Bcl-xL in complex with small molecule inhibitor
4QVF 1.53 Å, Crystal structure of Bcl-xL in complex with BIM BH3 domain
4A1U 1.54 Å, Crystal structure of alpha-beta-foldamer 2c in complex with Bcl-xL
6VWC 1.6 Å, Crystal structure of Bcl-xL in complex with tetrahydroisoquinoline-pyridine based…
6O0K 1.62 Å, crystal structure of BCL-2 with venetoclax
3SPF 1.7 Å, Crystal Structure of Bcl-xL bound to BM501
9I9E 1.7 Å, Structure of human Bcl-xL in complex with small molecule inhibitor
9O14 1.73 Å, Crystal Structure of BCL-2 in complex with a stapled BAD BH3 peptide BAD SAHB 4.2

Browse structure collections

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