Bcl-2-like protein 11 (BCL2L11) is a 198-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O43521.
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The mean pLDDT of this model is 60.1 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 7% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 35% |
| Below 50 | Very low: often disordered regions | 38% |
What pLDDT means and how to read it
Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis
Forms heterodimers with a number of antiapoptotic Bcl-2 proteins, including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1, BHRF1, and BCL2L2/BCLW (PubMed:11997495, PubMed:18812174, PubMed:27013495). Does not heterodimerize with proapoptotic proteins such as BAD, BOK or BAK. Identified in a complex containing BCL2L11, DYNLL1 and BCL2L1 isoform Bcl-X(L); BH3 integrity is required for…
Endomembrane system, Mitochondrion
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6X8O | X-ray | 1.31 Å | A/B/C/D=141-166 |
| 2WH6 | X-ray | 1.5 Å | B=141-166 |
| 4QVF | X-ray | 1.53 Å | B=141-166 |
| 4A1U | X-ray | 1.54 Å | B=146-163 |
| 2NL9 | X-ray | 1.55 Å | B=141-166 |
| 5VWY | X-ray | 1.55 Å | B=141-166 |
| 6UA3 | X-ray | 1.55 Å | B=146-166 |
| 5VX0 | X-ray | 1.6 Å | B/D=141-166 |
| 5VWZ | X-ray | 1.62 Å | B/D=141-166 |
| 3KJ0 | X-ray | 1.7 Å | B=143-165 |
| 3FDL | X-ray | 1.78 Å | B=141-166 |
| 2YQ6 | X-ray | 1.8 Å | B=147-164 |
| 4ZIE | X-ray | 1.8 Å | C=141-166 |
| 5VX2 | X-ray | 1.85 Å | B/D=141-166 |
| 2YQ7 | X-ray | 1.9 Å | B=147-164 |
| 4B4S | X-ray | 1.9 Å | B=141-166 |
| 5VWV | X-ray | 1.9 Å | B=141-165 |
| 3KJ1 | X-ray | 1.94 Å | B=143-163 |
| 5VX3 | X-ray | 1.95 Å | B/D/F/H=141-166 |
| 6VBX | X-ray | 1.95 Å | B=148-159 |
Showing 20 of 45 experimental structures (best resolution first).
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