30FM: Importin 7 L homeolog

Structure of histone H1 in an import-chaperone complex with importin beta and importin 7 (full-length model). Determined by electron microscopy at 3.6 Å resolution. Released 23 Sept 2026.

Method
Electron microscopy
Resolution
3.6 Å
Organisms
Xenopus laevis, Homo sapiens
Chains
3
Atoms
16,611
Mol. weight
237.8 kDa
Released
23 Sept 2026

Explore 30FM in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

30FM contains 125 α-helices and 4 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 68 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix3-1311
α-helix16-183
α-helix19-3012
α-helix35-4410
α-helix50-6718
α-helix78-814
α-helix85-10117
α-helix104-12118
α-helix128-13710
α-helix142-15817
α-helix164-19027
α-helix194-21118
α-helix222-23716
α-helix239-2402
α-helix249-2513
α-helix256-27015
α-helix271-2755
α-helix283-29513
α-helix297-31216
α-helix319-33214
α-helix336-34914
α-helix350-3545
α-helix355-3584
α-helix362-3709
α-helix372-3787
α-helix382-3876
α-helix389-40315
α-helix408-42013
α-helix426-43813
α-helix440-4456
α-helix450-4567
α-helix457-4615
α-helix462-4665
α-helix470-48213
α-helix491-50616
α-helix511-52717
α-helix531-5355
α-helix536-5383
α-helix539-55315
α-helix556-56813
α-helix570-5734
α-helix574-5763
α-helix577-59418
α-helix595-5973
α-helix601-62121
α-helix626-64520
α-helix649-6513
α-helix652-66312
α-helix671-6733
α-helix674-68411
α-helix687-6893
α-helix690-70213
α-helix705-7106
α-helix712-72716
α-helix732-74817
α-helix758-77013
α-helix776-79217
α-helix794-80310
α-helix813-82311
α-helix825-8273
α-helix831-84515
α-helix852-8565
α-helix858-8603
α-helix861-88424
α-helix910-92314
α-helix958-97215
α-helix974-9818
α-helix986-101328
Chain B: 52 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix3-97
α-helix15-3117
α-helix33-4513
α-helix51-6515
α-helix70-8112
α-helix85-9814
α-helix108-12013
α-helix121-1233
α-helix129-13810
α-helix144-16017
α-helix170-18112
α-helix188-20013
α-helix206-2105
α-helix212-22615
α-helix231-24717
α-helix253-2553
α-helix256-2605
α-helix261-2699
α-helix273-30230
α-helix314-32916
α-helix344-35916
α-helix360-3634
α-helix364-37411
α-helix380-39213
α-helix399-41618
α-helix422-43817
α-helix440-4434
α-helix449-45911
α-helix464-48421
α-helix500-5023
α-helix503-51412
α-helix521-5233
α-helix524-53714
α-helix541-5433
α-helix544-56320
α-helix571-59424
α-helix597-61721
α-helix622-63918
α-helix644-65916
α-helix664-68118
α-helix682-6843
α-helix686-70116
α-helix709-72416
α-helix725-7306
α-helix732-74413
α-helix752-77726
α-helix785-7939
α-helix794-80613
α-helix812-82817
α-helix831-8388
α-helix841-85212
α-helix856-87419
Chain C: 5 helices, 4 β-strands
ElementResiduesLengthSheet
α-helix28-3811
β-strand4511
α-helix47-5711
α-helix64-7815
β-strand81-8222
β-strand9311
β-strand94-9522
α-helix183-1853
α-helix188-1892

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Importin 7 L homeologAprotein1038Xenopus laevisO42480 (AlphaFold model)
Importin subunit beta-1Bprotein876Homo sapiensQ14974 (AlphaFold model)
Histone H1.0Cprotein195Homo sapiensP07305 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>30FM_1 Importin 7 L homeolog (chains A)
MDPNILIEALRGTMDPALREAAERQLNESHKSLHFVSTLLQITMSEQLELPVRQAGVIYL
KNMITQYWPDREVTPGELPPHTIPEEDRHCIRENIVEAIMHSPELIRVQLTTCIHHIIKH
DYPNRWTAVVEKIGFYLQSDNSACWLGILLCLYQLVKNYEYKKPEERSPLIAAMQHFLPM
LKDRYIQLLADPSEQSVLIQKQIFKIFYALVQYTLPLELINQQNLAEWIEILKTVVDRDV
PAETLQVDEDDRPELPWWKCKKWALHILARLFERYGSPGNVSKEYNDFAEVFLKAFAVGV
QQVLLKVLYQYKEKQYIAPRVLQQTLNYFNQGVSHAVTWKNLKPHIQGIIQDVIFPLMCY
TDSDEDLWQEDPYEYIRMKFDVFEDFISPTTAAQTLLFTSCSKRKEVLQKTMGFCYQILT
EPAADPRKKDGALHMIGSLAEILLKKKIYKDQMEFMLQNHVFPLFSSELGYMRARACWVL
HYFCEVKFKVDQNLQTALELTRRCLIDDREMPVKVEAAIALQVLISNQEKAKEYIVPFIR
PVMQALLHIIRETENDDLTNVIQKMICEYSEEVTPIAVEMTQHLAMTFNQVIQTGPDEEG
SDDKAVTAMGILNTIDTLLSVVEDHKEITQQLEGICLQVIGTVLQQHVLEFYEEIFSLAH
SLTCQQVSPQMWQLLPLVFDIFQQDGFDYFTDMMPLLHNYVTVDTDTLLSDTKYLEMIYS
MCKKILTGVAGEDAECHAAKLLEVVILQCKGRGIDQVIPLFVEAALERLTREVKTSELRT
MCLQVAIAALYYSPPLLFNTLENLRFPNNEEPVTNHFIKQWLNDVDCFLGLHDRKICVLG
LCALIELEQRPQVLNQMSSQILPAFLLLFNGLKRAYACHAEQENDSDDDGDGEDDEDAAE
LGSDEDDIDEEGQEYLEILAKQAGEDGDDEDWEDDDAEETALEGYTTLLDDEDTPIDEYQ
IFKAIFQKLQGRDPVWYQALTQGLNEDQGKQLQDIATLADQRRAAHESKMIEKHGGYKFN
APVVPSTFNFGNPAPGMN
Sequence of entity 2 (B), FASTA
>30FM_2 Importin subunit beta-1 (chains B)
MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQ
IKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAE
IPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQG
MRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQN
LVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEA
AEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCE
DDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDP
SVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEA
AYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSA
KDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDA
LQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKN
YAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDI
ALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQ
ENVHPDVMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEAR
PMIHELLTEGRRSKTNKAKTLATWATKELRKLKNQA
Sequence of entity 3 (C), FASTA
>30FM_3 Histone H1.0 (chains C)
GMTENSTSAPAAKPKRAKASKKSTDHPKYSDMIVAAIQAEKNRAGSSRQSIQKYIKSHYK
VGENADSQIKLSIKRLVTTGVLKQTKGVGASGSFRLAKSDEPKKSVAFKKTKKEIKKVAT
PKKASKPKKAASKAPTKKPKATPVKKAKKKLAATPKKAKKPKTVKAKPVKASKPKKAKPV
KPKAKSSAKRAGKKK

Primary citation

Chaperoning by dynamic encasement: Structural basis of linker histone H1 nuclear import. Fu, Z., Chafra, F., Freytag, B. et al. Structure (2026). DOI 10.1016/j.str.2026.09.001

Other PDB entries of the same protein (UniProt O42480 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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