Coagulation factor VIII, full-length, membrane-bound, on Ptd-choline : Ptd-serine 75:25 vesicles. Determined by electron microscopy at 3.15 Å resolution. Released 16 Sept 2026.
Explore 36JL in 3D Show helices and sheets RCSB PDB PDBe
36JL contains 27 α-helices and 105 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 2-14 | 13 | 1 |
| β-strand | 46-53 | 8 | 1 |
| β-strand | 54 | 1 | 2 |
| β-strand | 62 | 1 | 2 |
| α-helix | 63-66 | 4 | |
| α-helix | 67-69 | 3 | |
| α-helix | 72 | 1 | |
| β-strand | 73-78 | 6 | 3 |
| β-strand | 82-90 | 9 | 1 |
| β-strand | 96 | 1 | 4 |
| β-strand | 99 | 1 | 3 |
| β-strand | 104 | 1 | 1 |
| α-helix | 107-109 | 3 | |
| α-helix | 121-126 | 6 | |
| β-strand | 128 | 1 | 4 |
| β-strand | 133-140 | 8 | 1 |
| α-helix | 142-144 | 3 | |
| β-strand | 153-159 | 7 | 3 |
| α-helix | 164-170 | 7 | |
| β-strand | 173-179 | 7 | 3 |
| β-strand | 195-203 | 9 | 5 |
| α-helix | 204-206 | 3 | |
| β-strand | 230-234 | 5 | 5 |
| β-strand | 237 | 1 | 5 |
| α-helix | 239-241 | 3 | |
| β-strand | 245-248 | 4 | 6 |
| β-strand | 253-260 | 8 | 5 |
| β-strand | 267-271 | 5 | 6 |
| β-strand | 276-278 | 3 | 5 |
| β-strand | 281-283 | 3 | 5 |
| β-strand | 286-288 | 3 | 6 |
| β-strand | 293-298 | 6 | 5 |
| β-strand | 304-310 | 7 | 6 |
| α-helix | 313-315 | 3 | |
| β-strand | 322-327 | 6 | 6 |
| β-strand | 381 | 1 | 7 |
| β-strand | 387-388 | 2 | 8 |
| β-strand | 390-394 | 5 | 9 |
| α-helix | 407-411 | 5 | |
| β-strand | 422-426 | 5 | 9 |
| β-strand | 429 | 1 | 8 |
| β-strand | 453-456 | 4 | 10 |
| β-strand | 460 | 1 | 7 |
| β-strand | 464-467 | 4 | 8 |
| β-strand | 473 | 1 | 11 |
| β-strand | 476-478 | 3 | 10 |
| β-strand | 482-485 | 4 | 7 |
| α-helix | 501-502 | 2 | |
| β-strand | 503 | 1 | 11 |
| α-helix | 504 | 1 | |
| β-strand | 508-510 | 3 | 8 |
| β-strand | 511-514 | 4 | 7 |
| β-strand | 528-534 | 7 | 10 |
| α-helix | 539-544 | 6 | |
| β-strand | 549-554 | 6 | 10 |
| β-strand | 572-580 | 9 | 12 |
| α-helix | 587-591 | 5 | |
| α-helix | 606-609 | 4 | |
| β-strand | 613-617 | 5 | 12 |
| β-strand | 620 | 1 | 12 |
| β-strand | 622-629 | 8 | 13 |
| β-strand | 633-641 | 9 | 12 |
| β-strand | 649-652 | 4 | 14 |
| β-strand | 658-660 | 3 | 12 |
| β-strand | 663-665 | 3 | 12 |
| β-strand | 667-670 | 4 | 14 |
| β-strand | 675-682 | 8 | 12 |
| β-strand | 686-688 | 3 | 13 |
| β-strand | 691-692 | 2 | 14 |
| α-helix | 695-698 | 4 | |
| β-strand | 703-708 | 6 | 13 |
| β-strand | 1695-1707 | 13 | 15 |
| β-strand | 1730-1738 | 9 | 15 |
| β-strand | 1746 | 1 | 15 |
| α-helix | 1747-1749 | 3 | |
| α-helix | 1754-1756 | 3 | |
| β-strand | 1763-1766 | 4 | 16 |
| β-strand | 1770-1776 | 7 | 15 |
| β-strand | 1783 | 1 | 17 |
| β-strand | 1786-1787 | 2 | 16 |
| β-strand | 1807 | 1 | 17 |
| β-strand | 1812-1818 | 7 | 15 |
| α-helix | 1821-1823 | 3 | |
| β-strand | 1832-1838 | 7 | 16 |
| α-helix | 1845-1849 | 5 | |
| β-strand | 1853-1858 | 6 | 16 |
| β-strand | 1864 | 1 | 18 |
| β-strand | 1869 | 1 | 18 |
| β-strand | 1874-1884 | 11 | 19 |
| α-helix | 1885-1887 | 3 | |
| α-helix | 1891-1898 | 8 | |
| β-strand | 1917-1921 | 5 | 19 |
| β-strand | 1924 | 1 | 19 |
| β-strand | 1933-1935 | 3 | 20 |
| β-strand | 1940-1946 | 7 | 19 |
| β-strand | 1954-1958 | 5 | 20 |
| β-strand | 1963-1966 | 4 | 19 |
| β-strand | 1970-1973 | 4 | 19 |
| β-strand | 1975-1978 | 4 | 20 |
| β-strand | 1980 | 1 | 19 |
| β-strand | 1984-1988 | 5 | 19 |
| β-strand | 1994-2000 | 7 | 20 |
| α-helix | 2003-2008 | 6 | |
| β-strand | 2011-2017 | 7 | 20 |
| β-strand | 2023-2024 | 2 | 21 |
| α-helix | 2034-2036 | 3 | |
| β-strand | 2037-2039 | 3 | 21 |
| β-strand | 2043 | 1 | 22 |
| β-strand | 2046 | 1 | 22 |
| α-helix | 2048-2050 | 3 | |
| β-strand | 2062-2064 | 3 | 23 |
| β-strand | 2071-2087 | 17 | 21 |
| β-strand | 2097-2106 | 10 | 21 |
| β-strand | 2113-2114 | 2 | 21 |
| β-strand | 2126-2127 | 2 | 21 |
| β-strand | 2136-2157 | 22 | 21 |
| β-strand | 2159 | 1 | 21 |
| β-strand | 2160-2162 | 3 | 23 |
| β-strand | 2163-2169 | 7 | 21 |
| β-strand | 2177 | 1 | 24 |
| α-helix | 2187-2189 | 3 | |
| β-strand | 2192 | 1 | 24 |
| β-strand | 2197 | 1 | 25 |
| β-strand | 2202 | 1 | 25 |
| β-strand | 2230-2245 | 16 | 24 |
| β-strand | 2248-2250 | 3 | 26 |
| β-strand | 2253-2255 | 3 | 26 |
| β-strand | 2260-2265 | 6 | 24 |
| β-strand | 2272-2273 | 2 | 24 |
| β-strand | 2283 | 1 | 24 |
| β-strand | 2293-2310 | 18 | 24 |
| β-strand | 2322-2327 | 6 | 24 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Coagulation factor VIII | A | protein | 2332 | Homo sapiens | P00451 (AlphaFold model) |
>36JL_1 Coagulation factor VIII (chains A) ATRRYYLGAVELSWDYMQSDLGELPVDARFPPRVPKSFPFNTSVVYKKTLFVEFTDHLFN IAKPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGVSYWKASEGAEYDDQTSQ REKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVKDLNSGLIGALLVCR EGSLAKEKTQTLHKFILLFAVFDEGKSWHSETKNSLMQDRDAASARAWPKMHTVNGYVNR SLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHRQASLEISPITFLTAQTLL MDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQLRMKNNEEAEDYDDDLTDSEMDVVRF DDDNSPSFIQIRSVAKKHPKTWVHYIAAEEEDWDYAPLVLAPDDRSYKSQYLNNGPQRIG RKYKKVRFMAYTDETFKTREAIQHESGILGPLLYGEVGDTLLIIFKNQASRPYNIYPHGI TDVRPLYSRRLPKGVKHLKDFPILPGEIFKYKWTVTVEDGPTKSDPRCLTRYYSSFVNME RDLASGLIGPLLICYKESVDQRGNQIMSDKRNVILFSVFDENRSWYLTENIQRFLPNPAG VQLEDPEFQASNIMHSINGYVFDSLQLSVCLHEVAYWYILSIGAQTDFLSVFFSGYTFKH KMVYEDTLTLFPFSGETVFMSMENPGLWILGCHNSDFRNRGMTALLKVSSCDKNTGDYYE DSYEDISAYLLSKNNAIEPRSFSQNSRHPSTRQKQFNATTIPENDIEKTDPWFAHRTPMP KIQNVSSSDLLMLLRQSPTPHGLSLSDLQEAKYETFSDDPSPGAIDSNNSLSEMTHFRPQ LHHSGDMVFTPESGLQLRLNEKLGTTAATELKKLDFKVSSTSNNLISTIPSDNLAAGTDN TSSLGPPSMPVHYDSQLDTTLFGKKSSPLTESGGPLSLSEENNDSKLLESGLMNSQESSW GKNVSSTESGRLFKGKRAHGPALLTKDNALFKVSISLLKTNKTSNNSATNRKTHIDGPSL LIENSPSVWQNILESDTEFKKVTPLIHDRMLMDKNATALRLNHMSNKTTSSKNMEMVQQK KEGPIPPDAQNPDMSFFKMLFLPESARWIQRTHGKNSLNSGQGPSPKQLVSLGPEKSVEG QNFLSEKNKVVVGKGEFTKDVGLKEMVFPSSRNLFLTNLDNLHENNTHNQEKKIQEEIEK KETLIQENVVLPQIHTVTGTKNFMKNLFLLSTRQNVEGSYDGAYAPVLQDFRSLNDSTNR TKKHTAHFSKKGEEENLEGLGNQTKQIVEKYACTTRISPNTSQQNFVTQRSKRALKQFRL PLEETELEKRIIVDDTSTQWSKNMKHLTPSTLTQIDYNEKEKGAITQSPLSDCLTRSHSI PQANRSPLPIAKVSSFPSIRPIYLTRVLFQDNSSHLPAASYRKKDSGVQESSHFLQGAKK NNLSLAILTLEMTGDQREVGSLGTSATNSVTYKKVENTVLPKPDLPKTSGKVELLPKVHI YQKDLFPTETSNGSPGHLDLVEGSLLQGTEGAIKWNEANRPGKVPFLRVATESSAKTPSK LLDPLAWDNHYGTQIPKEEWKSQEKSPEKTAFKKKDTILSLNACESNHAIAAINEGQNKP EIEVTWAKQGRTERLCSQNPPVLKRHQREITRTTLQSDQEEIDYDDTISVEMKKEDFDIY DEDENQSPRSFQKKTRHYFIAAVERLWDYGMSSSPHVLRNRAQSGSVPQFKKVVFQEFTD GSFTQPLYRGELNEHLGLLGPYIRAEVEDNIMVTFRNQASRPYSFYSSLISYEEDQRQGA EPRKNFVKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSDVDLEKDVHSGLIGPLLVCHT NTLNPAHGRQVTVQEFALFFTIFDETKSWYFTENMERNCRAPCNIQMEDPTFKENYRFHA INGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSGHVFTVRKKEEYKMALYNLYP GVFETVEMLPSKAGIWRVECLIGEHLHAGMSTLFLVYSNKCQTPLGMASGHIRDFQITAS GQYGQWAPKLARLHYSGSINAWSTKEPFSWIKVDLLAPMIIHGIKTQGARQKFSSLYISQ FIIMYSLDGKKWQTYRGNSTGTLMVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRS TLRMELMGCDLNSCSMPLGMESKAISDAQITASSYFTNMFATWSPSKARLHLQGRSNAWR PQVNNPKEWLQVDFQKTMKVTGVTTQGVKSLLTSMYVKEFLISSSQDGHQWTLFFQNGKV KVFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGCEAQDLY
| ID | Name | Formula | Copies |
|---|---|---|---|
| CPS | 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate | C32 H58 N2 O7 S | 1 |
| SEP | Phosphoserine | C3 H8 N O6 P | 2 |
| CU1 | Copper (I) ion | Cu | 2 |
| CA | Calcium ion | Ca | 1 |
| NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose | C8 H15 N O6 | 2 |
Structural basis for membrane binding by coagulation factors V and VIII and their specificity for phosphatidylserine-containing membranes. Kolyadko, V.N., Pumroy, R.A., Moiseenkova-Bell, V.Y. et al. Proc Natl Acad Sci U S A (2026) 123:e2622255123-e2622255123. DOI 10.1073/pnas.2622255123 · PubMed
Other PDB entries of the same protein (UniProt P00451 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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