Coagulation factor VIII (F8) is a 2351-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P00451.
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The mean pLDDT of this model is 60.8 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 31% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 46% |
What pLDDT means and how to read it
Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa
Interacts with VWF/vWF. vWF binding is essential for the stabilization of F8 in circulation
Secreted, extracellular space
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3HNY | X-ray | 1.07 Å | M=2189-2347 |
| 3HNB | X-ray | 1.15 Å | M=2189-2347 |
| 1D7P | X-ray | 1.5 Å | M=2190-2348 |
| 9D5D | X-ray | 1.83 Å | M=2191-2351 |
| 1IQD | X-ray | 2.0 Å | C=2193-2348 |
| 3HOB | X-ray | 2.07 Å | A/M=2189-2347 |
| 4PT6 | X-ray | 2.1 Å | A/B=2190-2215, A/B=2222-2351 |
| 4KI5 | X-ray | 2.47 Å | M=2190-2351 |
| 4XZU | X-ray | 2.61 Å | G/M=2193-2346 |
| 7KWO | EM | 2.9 Å | A=1-2351 |
| 9JBV | EM | 3.17 Å | A=1-2351 |
| 6MF0 | X-ray | 3.2 Å | A/B=406-761, A/B=2039-2351 |
| 8TY1 | EM | 3.46 Å | A=406-761, A=2039-2351 |
| 6MF2 | X-ray | 3.61 Å | A=19-2351 |
| 2R7E | X-ray | 3.7 Å | A=19-760, B=1582-2351 |
| 7K66 | X-ray | 3.92 Å | A=406-761, A=2039-2351 |
| 3CDZ | X-ray | 3.98 Å | A=20-774, B=1668-2351 |
| 4BDV | X-ray | 3.98 Å | A=20-769, B=1667-2351 |
| 7KBT | X-ray | 4.15 Å | A=406-761, A=2039-2351 |
| 5K8D | X-ray | 4.19 Å | A=20-759, B=1713-2350 |
Showing 20 of 25 experimental structures (best resolution first).
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