3BPL: IL4-IL4R-Common Gamma ternary complex

Crystal structure of the IL4-IL4R-Common Gamma ternary complex. Determined by X-ray diffraction at 2.93 Å resolution. Released 5 Feb 2008.

Method: X-ray diffraction
Resolution: 2.93 Å
Organism: Homo sapiens
Chains: 3
Atoms: 4,534
Mol. weight: 64.03 kDa
Ligands: NAG
Released: 5 Feb 2008

Explore 3BPL in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3BPL contains 19 α-helices and 36 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 4 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	5-19	15
β-strand	28-30	3	1
α-helix	41-59	19
α-helix	70-94	25
β-strand	106-108	3	1
α-helix	109-126	18

Chain B: 8 helices, 18 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	2
β-strand	8-11	4	3
β-strand	16-22	7	3
β-strand	23	1	2
α-helix	29-32	4
β-strand	34-39	6	4
β-strand	47-49	3	4
α-helix	50-51	2
β-strand	52-53	2	3
β-strand	58-64	7	3
β-strand	74-80	7	4
β-strand	83-90	8	4
α-helix	92-94	3
β-strand	96	1	3
α-helix	98-101	4
β-strand	102-107	6	5
β-strand	113-119	7	5
α-helix	129-131	3
β-strand	133-140	8	6
β-strand	147-152	6	6
β-strand	158-162	5	5
α-helix	163-165	3
β-strand	171-179	9	6
α-helix	181-183	3
α-helix	189-192	4
β-strand	194-197	4	6

Chain C: 7 helices, 16 β-strands

Element	Residues	Length	Sheet
α-helix	36-38	3
β-strand	39-43	5	7
β-strand	47-51	5	7
α-helix	54-56	3
β-strand	64-69	6	8
β-strand	78-79	2	8
β-strand	83-86	4	7
β-strand	89-96	8	7
α-helix	97-99	3
β-strand	106-112	7	8
β-strand	115-124	10	8
α-helix	126-128	3
β-strand	130-131	2	7
α-helix	132-135	4
β-strand	136-142	7	9
β-strand	148-153	6	9
α-helix	158-160	3
β-strand	161-169	9	10
β-strand	176-180	5	10
β-strand	185-188	4	9
β-strand	197-205	9	10
α-helix	216-220	5
β-strand	222-224	3	10

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Interleukin-4	A	protein	129	Homo sapiens	P05112 (AlphaFold model)
Interleukin-4 receptor alpha chain	B	protein	205	Homo sapiens	P24394 (AlphaFold model)
Cytokine receptor common gamma chain	C	protein	199	Homo sapiens	P31785 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>3BPL_1 Interleukin-4 (chains A)
HKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAASKNTTEKETFCRAATVLRQFYSHHE
KDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIM
REKYSKCSS

Sequence of entity 2 (B), FASTA

>3BPL_2 Interleukin-4 receptor alpha chain (chains B)
ADPFKVLQEPTCVSDYMSISTCEWKMNGPTQCSTELRLLYQLVFLLSEAHTCIPENNGGA
GCVCHLLMDDVVSADQYTLDLWAGQQLLWKGSFKPSEHVKPRAPGNLTVHTQVSDTLLLT
WSNPYPPDNYLYNHLTYAVNIWSENDPADFRIYQVTYLEPSLRIAASTLKSGISYRARVR
AWAQCYNTTWSEWSPSTKWHNSYRE

Sequence of entity 3 (C), FASTA

>3BPL_3 Cytokine receptor common gamma chain (chains C)
PLPEVQCFVFNVEYMNCTWQSSSEPQPTNLTLHYWYKNSDNDKVQKCSHYLFSEEITSGC
QLQKKEIHLYQTFVVQLQDPREPRRQATQMLKLQNLVIPWAPENLTLHKLSESQLELNWN
NRFLNHCLEHLVQYRTDWDHSWTEQSVDYRHKFSLPSVDGQKRYTFRVRSRFNPLCGSAQ
HWSEWSHPIHWGSNTSKEN

Ligands and cofactors

ID	Name	Formula	Copies
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose	C8 H15 N O6	3

Primary citation

Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System. Laporte, S.L., Juo, Z.S., Vaclavikova, J. et al. Cell (2008) 132:259-272. DOI 10.1016/j.cell.2007.12.030 · PubMed

Other PDB entries of the same protein (UniProt P05112 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2D48 1.65 Å, Crystal structure of the Interleukin-4 variant T13D
2B8X 1.7 Å, Crystal structure of the interleukin-4 variant F82D
2B8U 1.8 Å, Crystal structure of wildtype human Interleukin-4
2B8Y 1.8 Å, Crystal structure of the interleukin-4 variant T13DF82D
2B91 2.0 Å, Crystal structure of the interleukin-4 variant F82DR85A
4YDY 2.0 Å, Crystal structure of darpin 44C12V5 in complex with human il-4
1HZI 2.05 Å, Interleukin-4 mutant E9A
2B90 2.1 Å, Crystal structure of the interleukin-4 variant T13DR85A
1RCB 2.25 Å, Crystal structure of human recombinant interleukin-4 at 2.25 Å resolution
1IAR 2.3 Å, Interleukin-4 / receptor alpha chain complex
2INT 2.35 Å, Crystal structure of recombinant human interleukin-4
2B8Z 2.5 Å, Crystal structure of the interleukin-4 variant R85A

Browse structure collections

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