3BPN: IL4-IL4R-IL13Ra ternary complex

Crystal structure of the IL4-IL4R-IL13Ra ternary complex. Determined by X-ray diffraction at 3.02 Å resolution. Released 5 Feb 2008.

Method: X-ray diffraction
Resolution: 3.02 Å
Organism: Homo sapiens
Chains: 3
Atoms: 5,094
Mol. weight: 75.26 kDa
Ligands: NAG
Released: 5 Feb 2008

Explore 3BPN in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3BPN contains 21 α-helices and 42 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 6 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	5-17	13
α-helix	24-26	3
β-strand	28-30	3	1
α-helix	41-59	19
α-helix	63-66	4
α-helix	70-94	25
β-strand	106-108	3	1
α-helix	109-126	18

Chain B: 7 helices, 17 β-strands

Element	Residues	Length	Sheet
β-strand	3-9	7	2
β-strand	11	1	3
β-strand	16-23	8	2
α-helix	29-32	4
β-strand	34-39	6	4
α-helix	44-45	2
β-strand	46-47	2	4
β-strand	52-53	2	2
β-strand	58-64	7	2
β-strand	74-79	6	4
β-strand	84-90	7	4
α-helix	92-94	3
β-strand	96	1	3
α-helix	98-101	4
β-strand	102-108	7	5
β-strand	113-119	7	5
β-strand	132-140	9	6
β-strand	147-152	6	6
β-strand	158-162	5	5
α-helix	163-165	3
β-strand	171-180	10	6
α-helix	181-183	3
α-helix	189-193	5
β-strand	194-197	4	6

Chain C: 8 helices, 23 β-strands

Element	Residues	Length	Sheet
α-helix	32-35	4
β-strand	36-43	8	7
β-strand	47-53	7	7
β-strand	65-70	6	1
α-helix	71-73	3
β-strand	77-79	3	1
β-strand	83-87	5	7
β-strand	94-101	8	1
β-strand	114-118	5	1
α-helix	119-121	3
β-strand	130-137	8	8
β-strand	141-147	7	8
β-strand	158-163	6	9
β-strand	171-172	2	9
β-strand	175-179	5	8
β-strand	182-188	7	8
β-strand	202-208	7	9
α-helix	214-215	2
β-strand	216-220	5	9
β-strand	226-227	2	8
α-helix	228-230	3
β-strand	232-239	8	10
β-strand	242-248	7	10
α-helix	249-250	2
α-helix	255-257	3
β-strand	258-266	9	11
β-strand	273-277	5	11
β-strand	294-299	6	10
β-strand	308-316	9	11
α-helix	329-333	5
β-strand	334-335	2	11

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Interleukin-4	A	protein	129	Homo sapiens	P05112 (AlphaFold model)
Interleukin-4 receptor alpha chain	B	protein	205	Homo sapiens	P24394 (AlphaFold model)
Interleukin-13 receptor alpha-1 chain	C	protein	314	Homo sapiens	P78552 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>3BPN_1 Interleukin-4 (chains A)
HKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAASKNTTEKETFCRAATVLRQFYSHHE
KDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIM
REKYSKCSS

Sequence of entity 2 (B), FASTA

>3BPN_2 Interleukin-4 receptor alpha chain (chains B)
ADPFKVLQEPTCVSDYMSISTCEWKMNGPTQCSTELRLLYQLVFLLSEAHTCIPENNGGA
GCVCHLLMDDVVSADQYTLDLWAGQQLLWKGSFKPSEHVKPRAPGNLTVHTQVSDTLLLT
WSNPYPPDNYLYNHLTYAVNIWSENDPADFRIYQVTYLEPSLRIAASTLKSGISYRARVR
AWAQCYNTTWSEWSPSTKWHNSYRE

Sequence of entity 3 (C), FASTA

>3BPN_3 Interleukin-13 receptor alpha-1 chain (chains C)
TETQPPVTNLSVSVENLCTVIWTWNPPEGASSNCSLWYFSHFGDKQDKKIAPETRRSIEV
PLNERICLQVGSQCSTNESEKPSILVEKCISPPEGDPESAVTELQCIWHNLSYMKCSWLP
GRNTSPDTNYTLYYWHRSLEKIHQCENIFREGQYFGCSFDLTKVKDSSFEQHSVQIMVKD
NAGKIKPSFNIVPLTSRVKPDPPHIKNLSFHNDDLYVQWENPQNFISRCLFYEVEVNNSQ
TETHNVFYVQEAKCENPEFERNVENTSCFMVPGVLPDTLNTVRIRVKTNKLCYEDDKLWS
NWSQEMSIGKKRNS

Ligands and cofactors

ID	Name	Formula	Copies
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose	C8 H15 N O6	2

Primary citation

Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System. Laporte, S.L., Juo, Z.S., Vaclavikova, J. et al. Cell (2008) 132:259-272. DOI 10.1016/j.cell.2007.12.030 · PubMed

Other PDB entries of the same protein (UniProt P05112 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2D48 1.65 Å, Crystal structure of the Interleukin-4 variant T13D
2B8X 1.7 Å, Crystal structure of the interleukin-4 variant F82D
2B8U 1.8 Å, Crystal structure of wildtype human Interleukin-4
2B8Y 1.8 Å, Crystal structure of the interleukin-4 variant T13DF82D
2B91 2.0 Å, Crystal structure of the interleukin-4 variant F82DR85A
4YDY 2.0 Å, Crystal structure of darpin 44C12V5 in complex with human il-4
1HZI 2.05 Å, Interleukin-4 mutant E9A
2B90 2.1 Å, Crystal structure of the interleukin-4 variant T13DR85A
1RCB 2.25 Å, Crystal structure of human recombinant interleukin-4 at 2.25 Å resolution
1IAR 2.3 Å, Interleukin-4 / receptor alpha chain complex
2INT 2.35 Å, Crystal structure of recombinant human interleukin-4
2B8Z 2.5 Å, Crystal structure of the interleukin-4 variant R85A

Browse structure collections

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