3HHR: Human growth hormone

Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Determined by X-ray diffraction at 2.8 Å resolution. Released 30 Apr 1994.

Method: X-ray diffraction
Resolution: 2.8 Å
Organism: Homo sapiens
Chains: 3
Atoms: 4,614
Mol. weight: 70.01 kDa
Released: 30 Apr 1994

Explore 3HHR in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3HHR contains 21 α-helices and 35 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 11 helices, 0 β-strands

Element	Residues	Length
α-helix	2-5	4
α-helix	6-35	30
α-helix	38-46	9
α-helix	48-50	3
α-helix	54-57	4
α-helix	64-67	4
α-helix	72-84	13
α-helix	89-93	5
α-helix	94-97	4
α-helix	107-127	21
α-helix	155-184	30

Chain B: 4 helices, 17 β-strands

Element	Residues	Length	Sheet
β-strand	35-39	5	1
β-strand	40	1	2
β-strand	46-50	5	1
β-strand	64-70	7	3
β-strand	81-82	2	3
β-strand	93-96	4	1
β-strand	106-113	8	3
β-strand	116-124	9	3
α-helix	125-127	3
β-strand	129	1	2
α-helix	131-134	4
β-strand	135-144	10	4
β-strand	150-158	9	4
α-helix	159-160	2
β-strand	172-180	9	5
α-helix	186	1
β-strand	187-188	2	5
β-strand	192	1	5
β-strand	196-203	8	4
β-strand	207-216	10	5
β-strand	229-232	4	5

Chain C: 6 helices, 18 β-strands

Element	Residues	Length	Sheet
β-strand	35-39	5	6
β-strand	40	1	7
β-strand	46-50	5	6
β-strand	66-70	5	8
β-strand	81-82	2	8
β-strand	93-96	4	6
α-helix	98-100	3
β-strand	107-113	7	8
β-strand	116-123	8	8
α-helix	126-128	3
β-strand	129	1	7
α-helix	131-134	4
β-strand	135-144	10	9
β-strand	150-158	9	9
α-helix	161-164	4
β-strand	172-180	9	10
α-helix	186	1
β-strand	187-188	2	10
β-strand	192	1	10
β-strand	196-203	8	9
β-strand	207-216	10	10
β-strand	225	1	10
α-helix	227-228	2
β-strand	229-232	4	10

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Human growth hormone	A	protein	190	Homo sapiens	P01241 (AlphaFold model)
Human growth hormone receptor (hghbp)	B, C	protein	205	Homo sapiens	P10912 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>3HHR_1 HUMAN GROWTH HORMONE (chains A)
FPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPT
PSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEG
IQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIV
QCRSVEGSCG

Sequence of entity 2 (B, C), FASTA

>3HHR_2 HUMAN GROWTH HORMONE RECEPTOR (hGHbp) (chains B, C)
EPKFTKCRSPERETFSCHWTDEVHHGTKNLGPIQLFYTRRNTQEWTQEWKECPDYVSAGE
NSCYFNSSFTSIWIPYCIKLTSNGGTVDEKCFSVDEIVQPDPPIALNWTLLNVSLTGIHA
DIQVRWEAPRNADIQKGWMVLEYELQYKEVNETKWKMMDPILTTSVPVYSLKVDKEYEVR
VRSKQRNSGNYGEFSEVLYVTLPQM

Primary citation

Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. de Vos, A.M., Ultsch, M., Kossiakoff, A.A. Science (1992) 255:306-312. PubMed

Other PDB entries of the same protein (UniProt P01241 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1HUW 2.0 Å, The crystal structure of affinity-matured human growth hormone at 2 Å resolution
1AXI 2.1 Å, Structural plasticity at the hgh:hghbp interface
1HGU 2.5 Å, Human growth hormone
1HWG 2.5 Å, 1:2 complex of human growth hormone with its soluble binding protein
1A22 2.6 Å, Human growth hormone bound to single receptor
1KF9 2.6 Å, Phage display derived variant of human growth hormone complexed with two copies of the…
1BP3 2.9 Å, The xray structure of a growth hormone-prolactin receptor complex
1HWH 2.9 Å, 1:1 complex of human growth hormone mutant G120R with its soluble binding protein

Browse more

3HHR is part of these collections:

Insulin and hormones

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