Crystal structure of the S1-cleaved Notch1 Negative Regulatory Region (NRR). Determined by X-ray diffraction at 3.2 Å resolution. Released 1 Sept 2009.
Explore 3I08 in 3D Show helices and sheets RCSB PDB PDBe
3I08 contains 33 α-helices and 20 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 1455-1458 | 4 | |
| α-helix | 1466-1468 | 3 | |
| α-helix | 1471-1473 | 3 | |
| α-helix | 1474-1477 | 4 | |
| α-helix | 1493-1495 | 3 | |
| α-helix | 1497-1499 | 3 | |
| α-helix | 1508-1510 | 3 | |
| α-helix | 1513-1520 | 8 | |
| α-helix | 1531-1538 | 8 | |
| α-helix | 1548-1550 | 3 | |
| α-helix | 1553-1560 | 8 | |
| β-strand | 1570 | 1 | 1 |
| α-helix | 1571 | 1 | |
| β-strand | 1572 | 1 | 2 |
| β-strand | 1574-1580 | 7 | 1 |
| α-helix | 1583-1588 | 6 | |
| α-helix | 1590-1601 | 12 | |
| β-strand | 1604-1607 | 4 | 1 |
| β-strand | 1609 | 1 | 3 |
| β-strand | 1615 | 1 | 3 |
| β-strand | 1617-1620 | 4 | 1 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 1674-1682 | 9 | 1 |
| α-helix | 1686-1689 | 4 | |
| β-strand | 1696 | 1 | 2 |
| α-helix | 1697-1709 | 13 | |
| β-strand | 1718-1725 | 8 | 1 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 1455-1458 | 4 | |
| α-helix | 1466-1468 | 3 | |
| α-helix | 1476-1478 | 3 | |
| α-helix | 1487-1490 | 4 | |
| α-helix | 1493-1495 | 3 | |
| α-helix | 1497-1499 | 3 | |
| α-helix | 1508-1510 | 3 | |
| α-helix | 1513-1520 | 8 | |
| α-helix | 1529-1530 | 2 | |
| α-helix | 1531-1540 | 10 | |
| α-helix | 1548-1550 | 3 | |
| α-helix | 1553-1560 | 8 | |
| β-strand | 1570 | 1 | 4 |
| α-helix | 1571 | 1 | |
| β-strand | 1572 | 1 | 5 |
| β-strand | 1575-1579 | 5 | 4 |
| α-helix | 1583-1588 | 6 | |
| α-helix | 1590-1601 | 12 | |
| β-strand | 1604-1607 | 4 | 4 |
| β-strand | 1609 | 1 | 6 |
| β-strand | 1615 | 1 | 6 |
| β-strand | 1617-1620 | 4 | 4 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 1674-1682 | 9 | 4 |
| α-helix | 1686-1689 | 4 | |
| β-strand | 1696 | 1 | 5 |
| α-helix | 1697-1709 | 13 | |
| β-strand | 1719-1724 | 6 | 4 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Neurogenic locus notch homolog protein 1 | A, C | protein | 220 | Homo sapiens | P46531 (AlphaFold model) |
| Neurogenic locus notch homolog protein 1 | B, D | protein | 69 | Homo sapiens | P46531 (AlphaFold model) |
>3I08_1 Neurogenic locus notch homolog protein 1 (chains A, C) GEEACELPECQEDAGNKVCSLQCNNHACGWDGGDCSLNFNDPWKNCTQSLQCWKYFSDGH CDSQCNSAGCLFDGFDCQRAEGQCNPLYDQYCKDHFSDGHCDQGCNSAECEWDGLDCAEH VPERLAAGTLVVVVLMPPEQLRNSSFHFLRELSRVLHTNVVFKRDAHGQQMIFPYYGREE ELRKHPIKRAAEGWAAPDALLGQVKASLLPGGSEGGRRRR
>3I08_2 Neurogenic locus notch homolog protein 1 (chains B, D) ELDPMDVRGSIVYLEIDNRQCVQASSQCFQSATDVAAFLGALASLGSLNIPYKIEAVQSE TVEPPPPAQ
| ID | Name | Formula | Copies |
|---|---|---|---|
| CA | Calcium ion | Ca | 6 |
Water and common crystallization additives (CL) are not listed.
Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2. Gordon, W.R., Vardar-Ulu, D., L'Heureux, S. et al. PLoS One (2009) 4:e6613-e6613. DOI 10.1371/journal.pone.0006613 · PubMed
Other PDB entries of the same protein (UniProt P46531 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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