3IFD: C-C motif chemokine 2

Human synthetic monocyte chemoattractant protein 1 (MCP-1). Determined by X-ray diffraction at 1.9 Å resolution. Released 4 Aug 2009.

Method: X-ray diffraction
Resolution: 1.9 Å
Organism: Homo sapiens
Chains: 1
Atoms: 554
Mol. weight: 8.83 kDa
Ligands: PO4
Released: 4 Aug 2009

Explore 3IFD in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3IFD contains 2 α-helices and 3 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	19-21	3
β-strand	25-31	7	1
β-strand	40-45	6	1
β-strand	50-53	4	1
α-helix	58-69	12

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
C-C motif chemokine 2	A	protein	76	Homo sapiens	P13500 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>3IFD_1 C-C motif chemokine 2 (chains A)
QPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWV
QDSMDHLDKQTQTPKT

Ligands and cofactors

ID	Name	Formula	Copies
PO4	Phosphate ion	O4 P	1

Water and common crystallization additives (K) are not listed.

Primary citation

Synthesis by native chemical ligation and crystal structure of human CCL2. Grygiel, T.L., Teplyakov, A., Obmolova, G. et al. Biopolymers (2010) 94:350-359. DOI 10.1002/bip.21390 · PubMed

Other PDB entries of the same protein (UniProt P13500 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7SO0 1.74 Å, Crystal Structure of the Engineered Tick Evasin EVA-P974(F31A) Complexed to Human…
1DOK 1.85 Å, Monocyte chemoattractant protein 1, P-form
4R8I 2.05 Å, High Resolution Structure of a Mirror-Image RNA Oligonucleotide Aptamer in Complex with…
1DOL 2.4 Å, Monocyte chemoattractant protein 1, I-form
2NZ1 2.5 Å, Viral Chemokine Binding Protein M3 From Murine Gammaherpesvirus68 In Complex With The…
2BDN 2.53 Å, Crystal structure of human MCP-1 bound to a blocking antibody, 11K2
4ZK9 2.6 Å, The chemokine binding protein of orf virus complexed with CCL2
1ML0 2.8 Å, Viral chemokine binding protein M3 from murine GAMMAHERPESVIRUS68 in complex with the…
4DN4 2.8 Å, Crystal structure of the complex between cnto888 fab and mcp-1 mutant p8a
7XA3 2.9 Å, Cryo-EM structure of the CCL2 bound CCR2-Gi complex
8FJ0 2.91 Å, Crystal Structure of the Tick Evasin EVA-AAM1001(Y44A) Complexed to Human Chemokine CCL2
1DOM Solution structure of the monocyte chemoattractant protein-1 dimer using heteronuclear,…

Browse structure collections

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