3INK: Unraveling the structure of interleukin-2: reply

Unraveling the structure of interleukin-2: reply. Determined by X-ray diffraction at 2.5 Å resolution. Released 31 Oct 1993.

Method: X-ray diffraction
Resolution: 2.5 Å
Organism: Homo sapiens
Chains: 2
Atoms: 1,996
Mol. weight: 30.81 kDa
Released: 31 Oct 1993

Explore 3INK in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3INK contains 17 α-helices and 4 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain C: 8 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	7-28	22
α-helix	36-39	4
β-strand	44-47	4	1
α-helix	53-56	4
α-helix	57-60	4
α-helix	63-70	8
α-helix	75-77	3
α-helix	82-96	15
β-strand	107-112	6	1
α-helix	114-129	16

Chain D: 9 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	7-28	22
α-helix	36-39	4
β-strand	44	1	2
α-helix	45-47	3
α-helix	53-56	4
α-helix	57-60	4
α-helix	63-70	8
α-helix	75-77	3
α-helix	82-96	15
β-strand	112	1	2
α-helix	114-132	19

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Interleukin-2	C, D	protein	133	Homo sapiens	P60568 (AlphaFold model)

Sequence of entity 1 (C, D), FASTA

>3INK_1 INTERLEUKIN-2 (chains C, D)
APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLE
EELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNR
WITFAQSIISTLT

Primary citation

Response. McKay, D.B. Science (1992) 257:412-413. DOI 10.1126/science.257.5068.412 · PubMed

Other PDB entries of the same protein (UniProt P60568 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8SOZ 1.64 Å, Structure of the complex formed by human interleukin-2 and scFv 602
8SOW 1.71 Å, Structure of the complex formed by human interleukin-2 and scFv F10
7M2G 1.79 Å, INTERLEUKIN-2 (human) mutant P65K, C125S
4NEJ 1.92 Å, Small molecular fragment bound to crystal contact interface of Interleukin-2
4NEM 1.93 Å, Small molecular fragment bound to crystal contact interface of Interleukin-2
1M48 1.95 Å, Crystal Structure of Human IL-2 Complexed with (R)-N-[2-[1-(Aminoiminomethyl)-3-piperidin…
5LQB 1.95 Å, Complex structure of human IL2 mutant, Proleukin, with Fab fragment of NARA1 antibody
1M47 1.99 Å, Crystal Structure of Human Interleukin-2
1M49 2.0 Å, Crystal Structure of Human Interleukin-2 Complexed with SP-1985
1M4B 2.15 Å, Crystal Structure of Human Interleukin-2 K43C Covalently Modified at C43 with…
1M4A 2.18 Å, Crystal Structure of Human Interleukin-2 Y31C Covalently Modified at C31 with…
1NBP 2.2 Å, Crystal Structure Of Human Interleukin-2 Y31C Covalently Modified At C31 With…

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