Small molecular fragment bound to crystal contact interface of Interleukin-2. Determined by X-ray diffraction at 1.93 Å resolution. Released 19 Nov 2014.
Explore 4NEM in 3D Show helices and sheets RCSB PDB PDBe
4NEM contains 8 α-helices and 4 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 7-28 | 22 | |
| α-helix | 36-39 | 4 | |
| β-strand | 44 | 1 | 1 |
| β-strand | 47 | 1 | 2 |
| α-helix | 53-56 | 4 | |
| α-helix | 57-60 | 4 | |
| α-helix | 63-71 | 9 | |
| α-helix | 85-96 | 12 | |
| α-helix | 104-106 | 3 | |
| β-strand | 107 | 1 | 2 |
| β-strand | 112 | 1 | 1 |
| α-helix | 114-130 | 17 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Interleukin-2 | A | protein | 130 | Homo sapiens | P60568 (AlphaFold model) |
>4NEM_1 Interleukin-2 (chains A) SSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEEL KPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWIT FSQSIISTLT
| ID | Name | Formula | Copies |
|---|---|---|---|
| 2JY | 5-[(2,3-dichlorophenoxy)methyl]furan-2-carboxylic acid | C12 H8 Cl2 O4 | 1 |
Small molecular fragments bound to binding energy hot-spot in crystal contact interface of Interleukin-2. Jehle, S., Brenke, R., Vajda, S. et al. To be published.
Other PDB entries of the same protein (UniProt P60568 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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