3JZQ: Protein Mdm4

Human MDMX liganded with a 12mer peptide inhibitor (pDIQ). Determined by X-ray diffraction at 1.8 Å resolution. Released 10 Nov 2009.

Method: X-ray diffraction
Resolution: 1.8 Å
Organism: Homo sapiens
Chains: 4
Atoms: 1,735
Mol. weight: 23.55 kDa
Released: 10 Nov 2009

Explore 3JZQ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3JZQ contains 10 α-helices and 14 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 4 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	27	1	1
β-strand	28-29	2	2
α-helix	31-39	9
β-strand	47	1	1
α-helix	49-62	14
β-strand	66	1	3
β-strand	73-75	3	3
α-helix	80-85	6
β-strand	89-91	3	3
α-helix	96-105	10
β-strand	106-107	2	2

Chain B: 4 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	27	1	4
β-strand	28-29	2	5
α-helix	31-39	9
β-strand	47	1	4
α-helix	49-63	15
β-strand	66-67	2	6
β-strand	70-75	6	6
α-helix	80-85	6
β-strand	89-91	3	6
α-helix	96-105	10
β-strand	106-107	2	5

Chains P and Q: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	3-8	6

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Protein Mdm4	A, B	protein	89	Homo sapiens	O15151 (AlphaFold model)
pDIQ peptide (12mer)	P, Q	protein	12

Sequence of entity 1 (A, B), FASTA

>3JZQ_1 Protein Mdm4 (chains A, B)
QINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLG
ELLGRQSFSVKDPSPLYDMLRKNLVTLAT

Sequence of entity 2 (P, Q), FASTA

>3JZQ_2 pDIQ peptide (12mer) (chains P, Q)
ETFEHWWSQLLS

Primary citation

Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX. Phan, J., Li, Z., Kasprzak, A. et al. J Biol Chem (2010) 285:2174-2183. DOI 10.1074/jbc.M109.073056 · PubMed

Other PDB entries of the same protein (UniProt O15151 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6Q9Y 1.2 Å, HDMX (14-111; C17S) COMPLEXED WITH COMPOUND 16 AT 1.20A; Structural states of Hdm2 and…
3FEA 1.33 Å, Crystal Structure of HdmX bound to the p53-peptidomimetic…
3FE7 1.35 Å, Crystal Structure of HdmX bound to the p53-peptidomimetic…
3FDO 1.4 Å, Structure of human MDMX in complex with high affinity peptide
3LBJ 1.5 Å, Structure of human MDMX protein in complex with a small molecule inhibitor
4RXZ 1.55 Å, Crystal Structure of MDMX phosporylated Tyr99 in complex with a 12-mer peptide
6Q9W 1.55 Å, X-ray structure of compound 15 bound to HdmX: Structural states of Hdm2 and HdmX: X-ray…
3EQY 1.63 Å, Crystal structure of human MDMX in complex with a 12-mer peptide inhibitor
7C3Y 1.63 Å, Crystal structure of the N-terminal domain of human MdmX protein in complex with Nutlin3a
7C44 1.65 Å, Crystal structure of the p53-binding domain of human MdmX protein in complex with Nutlin3a
8HDG 1.73 Å, Small peptide enhances the binding of nutline-3a to MdmX
3JZP 1.74 Å, Human MDMX liganded with a 12mer peptide inhibitor (pDI6W)

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