3LW0: IGF-1RK

IGF-1RK in complex with ligand MSC1609119A-1. Determined by X-ray diffraction at 1.79 Å resolution. Released 29 Sept 2010.

Method: X-ray diffraction
Resolution: 1.79 Å
Organism: Homo sapiens
Chains: 4
Atoms: 10,929
Mol. weight: 142.33 kDa
Ligands: CCX
Released: 29 Sept 2010

Explore 3LW0 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3LW0 contains 80 α-helices and 48 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A, B and D: 20 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	993	1	1
α-helix	996-998	3
β-strand	999-1007	9	1
β-strand	1012-1022	11	1
β-strand	1025-1034	10	1
α-helix	1041-1054	14
β-strand	1062	1	2
α-helix	1063-1064	2
β-strand	1065-1069	5	1
β-strand	1076-1080	5	1
β-strand	1086	1	2
α-helix	1087-1093	7
α-helix	1109-1128	20
α-helix	1138-1140	3
β-strand	1141-1143	3	2
β-strand	1149-1151	3	2
α-helix	1162-1164	3
β-strand	1166	1	3
β-strand	1174	1	3
α-helix	1176-1178	3
α-helix	1181-1186	6
α-helix	1191-1207	17
α-helix	1210-1211	2
α-helix	1218-1226	9
α-helix	1231-1234	4
α-helix	1239-1248	10
α-helix	1253-1255	3
α-helix	1257-1258	2
α-helix	1259-1266	8
α-helix	1267-1269	3
α-helix	1271	1
α-helix	1274-1277	4

Chain C: 20 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	993	1	7
α-helix	996-998	3
β-strand	999-1007	9	7
β-strand	1012-1022	11	7
β-strand	1025-1034	10	7
α-helix	1041-1054	14
β-strand	1062	1	8
α-helix	1063-1064	2
β-strand	1065-1069	5	7
β-strand	1076-1080	5	7
β-strand	1085-1086	2	8
α-helix	1087-1093	7
α-helix	1109-1128	20
α-helix	1138-1140	3
β-strand	1141-1143	3	8
β-strand	1149-1151	3	8
α-helix	1162-1164	3
β-strand	1166	1	9
β-strand	1174	1	9
α-helix	1176-1178	3
α-helix	1181-1186	6
α-helix	1191-1207	17
α-helix	1210-1211	2
α-helix	1218-1226	9
α-helix	1231-1234	4
α-helix	1239-1248	10
α-helix	1253-1255	3
α-helix	1257-1258	2
α-helix	1259-1266	8
α-helix	1267-1269	3
α-helix	1271	1
α-helix	1274-1277	4

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Insulin-like growth factor 1 receptor	A, B, C, D	protein	304	Homo sapiens	P08069 (AlphaFold model)

Sequence of entity 1 (A, B, C, D), FASTA

>3LW0_1 Insulin-like growth factor 1 receptor (chains A, B, C, D)
AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMR
ERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPAMANNP
VLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYE
TDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVL
RFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYS
EENK

Ligands and cofactors

ID	Name	Formula	Copies
CCX	3-cyano-N-{1-[4-(5-cyano-1H-indol-3-yl)butyl]piperidin-4-yl}-1H-indole-7-carbox…	C28 H28 N6 O	8

Water and common crystallization additives (GOL) are not listed.

Primary citation

Allosteric IGF-1R Inhibitors. Heinrich, T., Gradler, U., Bottcher, H. et al. ACS Med Chem Lett (2010) 1:199-203. DOI 10.1021/ml100044h · PubMed

Other PDB entries of the same protein (UniProt P08069 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1P4O 1.5 Å, Structure of Apo unactivated IGF-1R KInase domain at 1.5A resolution.
8PYN 1.71 Å, Human IGF1R with inhibitor 56
5FXS 1.9 Å, IGFR-1R complex with a pyrimidine inhibitor.
2OJ9 2.0 Å, Structure of IGF-1R kinase domain complexed with a benzimidazole inhibitor
3I81 2.08 Å, Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with…
1JQH 2.1 Å, IGF-1 receptor kinase domain
1K3A 2.1 Å, Structure of the Insulin-like Growth Factor 1 Receptor Kinase
3O23 2.1 Å, Human unphosphorylated IGF1-R Kinase domain in complex with an hydantoin inhibitor
4D2R 2.1 Å, Human IGF in complex with a Dyrk1B inhibitor
3NW7 2.11 Å, Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with a…
3NW5 2.14 Å, Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with a…
3NW6 2.2 Å, Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with a…

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