3N4R: Csm1 C-terminal domain, R3 form

Structure of Csm1 C-terminal domain, R3 form. Determined by X-ray diffraction at 2.6 Å resolution. Released 1 Sept 2010.

Method: X-ray diffraction
Resolution: 2.6 Å
Organism: Saccharomyces cerevisiae
Chains: 4
Atoms: 3,221
Mol. weight: 54.76 kDa
Ligands: MLI
Released: 1 Sept 2010

Explore 3N4R in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3N4R contains 20 α-helices and 20 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 5 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	71-82	12
β-strand	84-89	6	1
β-strand	96-102	7	1
β-strand	116-122	7	1
β-strand	132-136	5	1
α-helix	143-152	10
α-helix	155-158	4
β-strand	161-163	3	1
α-helix	165-167	3
α-helix	168-176	9

Chain B: 5 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	71-82	12
β-strand	84-92	9	2
β-strand	95-102	8	2
β-strand	116-122	7	2
β-strand	132-136	5	2
α-helix	143-150	8
α-helix	155-158	4
β-strand	161-163	3	2
α-helix	165-167	3
α-helix	168-178	11

Chain C: 5 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	69-82	14
β-strand	84-91	8	3
β-strand	95-103	9	3
β-strand	115-123	9	3
β-strand	131-136	6	3
α-helix	143-152	10
α-helix	155-158	4
β-strand	161-164	4	3
α-helix	165-167	3
α-helix	168-178	11

Chain D: 5 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	67-82	16
β-strand	84-86	3	4
β-strand	97-103	7	4
β-strand	115-121	7	4
β-strand	131-136	6	4
α-helix	143-152	10
α-helix	155-158	4
β-strand	161-164	4	4
α-helix	165-167	3
α-helix	168-179	12

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Monopolin complex subunit CSM1	A, B, C, D	protein	116	Saccharomyces cerevisiae	P25651 (AlphaFold model)

Sequence of entity 1 (A, B, C, D), FASTA

>3N4R_1 Monopolin complex subunit CSM1 (chains A, B, C, D)
SNAENSEVIKDLYEYLCNVRVHKSYEDDSGLWFDISQGTHSGGSSDDYSIMDYKLGFVKG
QAQVTEVIYAPVLKQRSTEELYSLQSKLPEYMFETLSFPLSSLNQFYNKIAKSLNK

Ligands and cofactors

ID	Name	Formula	Copies
MLI	Malonate ion	C3 H2 O4	3

Water and common crystallization additives (1PE) are not listed.

Primary citation

The Monopolin Complex Crosslinks Kinetochore Components to Regulate Chromosome-Microtubule Attachments. Corbett, K.D., Yip, C.K., Ee, L.S. et al. Cell (2010) 142:556-567. DOI 10.1016/j.cell.2010.07.017 · PubMed

Other PDB entries of the same protein (UniProt P25651 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5V3N 1.3 Å, Structure of S. cerevisiae Ulp2-Tof2-Csm1 complex
6DEI 1.7 Å, Structure of Dse3-Csm1 complex
5V1A 2.14 Å, Structure of S. cerevisiae Ulp2:Csm1 complex
3N4S 2.35 Å, Structure of Csm1 C-terminal domain, P21212 form
5KTB 3.05 Å, Structure of a complex between S. cerevisiae Csm1 and Mam1
3N4X 3.41 Å, Structure of Csm1 full-length
3N7N 3.9 Å, Structure of Csm1/Lrs4 complex

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