3O9Q: Nonstructural protein 1

Effector domain of NS1 from A/PR/8/34 containing a W187A mutation. Determined by X-ray diffraction at 2.5 Å resolution. Released 18 May 2011.

Method: X-ray diffraction
Resolution: 2.5 Å
Organism: Influenza A virus
Chains: 2
Atoms: 1,939
Mol. weight: 33.75 kDa
Released: 18 May 2011

Explore 3O9Q in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3O9Q contains 6 α-helices and 14 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 3 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	88-91	4	1
β-strand	107-112	6	1
β-strand	115-120	6	1
β-strand	127-137	11	1
β-strand	140-151	12	1
β-strand	156-162	7	1
α-helix	167-169	3
α-helix	171-187	17
β-strand	191-194	4	1
α-helix	196-203	8

Chain B: 3 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	88-91	4	1
α-helix	95-99	5
β-strand	107-112	6	1
β-strand	115-120	6	1
β-strand	127-137	11	1
β-strand	140-151	12	1
β-strand	156-162	7	1
α-helix	171-187	17
β-strand	191-194	4	1
α-helix	196-204	9

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Nonstructural protein 1	A, B	protein	152	Influenza A virus	P03496 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>3O9Q_1 Nonstructural protein 1 (chains A, B)
MTMASVPASRYLTDMTLEEMSRDWSMLIPKQKVAGPLCIRMDQAIMDKNIILKANFSVIF
DRLETLILLRAFTEEGAIVGEISPLPSLPGHTAEDVKNAVGVLIGGLEANDNTVRVSETL
QRFAWRSSNENGRPPLTPKQKREMAGTIRSEV

Primary citation

A Transient Homotypic Interaction Model for the Influenza A Virus NS1 Protein Effector Domain. Kerry, P.S., Ayllon, J., Taylor, M.A. et al. PLoS One (2011) 6:e17946-e17946. DOI 10.1371/journal.pone.0017946 · PubMed

Other PDB entries of the same protein (UniProt P03496 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2ZKO 1.7 Å, Structural basis for dsRNA recognition by NS1 protein of human influenza virus A
3RVC 1.8 Å, Effector domain of NS1 from influenza A/PR/8/34 containing a W187A mutation
3O9R 2.0 Å, Effector domain of NS1 from influenza A/PR/8/34 containing a W187A mutation
2GX9 2.1 Å, X-ray structure of influenza virus NS1 effector domain
3O9T 2.2 Å, Effector domain from influenza A/PR/8/34 NS1
3L4Q 2.3 Å, Structural insights into phosphoinositide 3-kinase activation by the influenza A virus…
3O9S 2.48 Å, Effector domain of influenza A/PR/8/34 NS1
5NT1 2.82 Å, Complex of influenza A NS1 effector domain with TRIM25 coiled coil
3O9U 3.2 Å, Effector domain of influenza A/PR/8/34 NS1
5NT2 4.26 Å, Complex of influenza A NS1 with TRIM25 coiled coil domain

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