3OLL: Estrogen receptor beta

Crystal structure of phosphorylated estrogen receptor beta ligand binding domain. Determined by X-ray diffraction at 1.5 Å resolution. Released 17 Nov 2010.

Method: X-ray diffraction
Resolution: 1.5 Å
Organism: Homo sapiens
Chains: 4
Atoms: 4,521
Mol. weight: 59.39 kDa
Ligands: EST
Released: 17 Nov 2010

Explore 3OLL in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3OLL contains 26 α-helices and 8 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 12 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	265-275	11
α-helix	276-281	6
β-strand	283	1	1
α-helix	288-289	2
α-helix	291-314	24
α-helix	319-321	3
α-helix	324-347	24
β-strand	353-357	5	2
β-strand	359	1	1
β-strand	360-363	4	2
α-helix	364-369	6
α-helix	373-389	17
α-helix	394-406	13
α-helix	421-442	22
α-helix	448-481	34
α-helix	489-497	9

Chain B: 12 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	265-274	10
α-helix	276-281	6
β-strand	283	1	3
α-helix	288-289	2
α-helix	291-314	24
α-helix	319-321	3
α-helix	324-347	24
β-strand	353-357	5	4
β-strand	359	1	3
β-strand	360-363	4	4
α-helix	364-369	6
α-helix	373-389	17
α-helix	394-406	13
α-helix	422-442	21
α-helix	448-481	34
α-helix	489-497	9

Chains C and D: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	3-9	7

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Estrogen receptor beta	A, B	protein	240	Homo sapiens	Q92731 (AlphaFold model)
Nuclear receptor coactivator 1	C, D	protein	19	Homo sapiens	Q15788 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>3OLL_1 Estrogen receptor beta (chains A, B)
DALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFV
ELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDML
LATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWV
IAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVL

Sequence of entity 2 (C, D), FASTA

>3OLL_2 Nuclear receptor coactivator 1 (chains C, D)
LTERHKILHRLLQEGSPSD

Ligands and cofactors

ID	Name	Formula	Copies
EST	Estradiol	C18 H24 O2	2

Primary citation

Synthesis and crystal structure of a phosphorylated estrogen receptor ligand binding domain. Mocklinghoff, S., Rose, R., Carraz, M. et al. Chembiochem (2010) 11:2251-2254. DOI 10.1002/cbic.201000532 · PubMed

Other PDB entries of the same protein (UniProt Q92731 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7XVY 1.54 Å, Human Estrogen Receptor beta Ligand-binding Domain in Complex with S-DPN
1QKM 1.8 Å, Human oestrogen receptor beta ligand-binding domain in complex with partial agonist…
7XWQ 1.89 Å, Human Estrogen Receptor beta Ligand-binding Domain in Complex with…
7XWP 1.92 Å, Human Estrogen Receptor beta Ligand-binding Domain in Complex with…
2YJD 1.93 Å, Stapled peptide bound to Estrogen Receptor Beta
3OMQ 1.97 Å, Fragment-Based Design of novel Estrogen Receptor Ligands
9ECF 2.0 Å, Crystal structure of the hERbeta LBD complexed with androstenediol and SRC 2-2 peptide…
1YYE 2.03 Å, Crystal structure of estrogen receptor beta complexed with way-202196
3OMP 2.05 Å, Fragment-Based Design of novel Estrogen Receptor Ligands
7XVZ 2.08 Å, Human Estrogen Receptor beta Ligand-binding Domain in Complex with…
2NV7 2.1 Å, Crystal Structure of Estrogen Receptor Beta Complexed with WAY-555
4J24 2.1 Å, Estrogen Receptor in complex with proline-flanked LXXLL peptides

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